CAR/NR1I3 Antibody Pair

Product Discontinued

CAR/NR1I3 Antibody Pair Summary

• Description: Quality control test: Immunoprecipitation-Western Blot (IP-WB). This IP-WB antibody pair set comes with one antibody for immunoprecipitation and another to detect the precipitated protein in western blot.
  
  
• Antibody pair for IP: rabbit polyclonal anti-NR1I3 (300 ul)
• Antibody pair for WB: mouse purified polyclonal anti-NR1I3 (50 ug)
• Clonality: Polyclonal
• Gene: NR1I3
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunoprecipitation
  • Western Blot

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: 1x PBS, pH 7.4
• Preservative: No Preservative
• Purity: Immunogen affinity purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for CAR/NR1I3 Antibody Pair

• CAR
• CARCAR1
• Constitutive activator of retinoid response
• constitutive active receptor
• Constitutive active response
• Constitutive androstane receptor
• MB67
• MGC150433
• MGC97144
• MGC97209
• NR1I3
• nuclear receptor subfamily 1 group I member 3
• nuclear receptor subfamily 1, group I, member 3
• orphan nuclear hormone receptor
• Orphan nuclear receptor MB67

Background

NR1I3 encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Antibody Pairs are guaranteed for 6 months from date of receipt.

Bioinformatics

• Gene Symbol: NR1I3