Calcium-sensing R/CaSR Antibody

Images

 
Immunohistochemistry-Paraffin: Calcium-sensing R/CaSR Antibody [NLS1425] - Anti-CASR/Calcium Sensing Receptor antibody IHC of human kidney, diabetes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue ...read more
Immunohistochemistry-Paraffin: Calcium-sensing R/CaSR Antibody [NLS1425] - Analysis of anti-CASR antibody with human parathyroid.
Immunohistochemistry-Paraffin: Calcium-sensing R/CaSR Antibody [NLS1425] - Anti-CASR/Calcium Sensing Receptor antibody IHC of human Thyroid, Medullary Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded ...read more

Product Details

Summary
Reactivity Hu, Mu, Rt, Po, Bt, Bv, Ca, Ch, Eq, Ha, Mk, Pm, Rb, Op, Tr, XpSpecies Glossary
Applications IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Order Details

Calcium-sensing R/CaSR Antibody Summary

Immunogen
Synthetic 17 amino acid peptide from N-terminal extracellular domain of human CASR.
Localization
Integral membrane protein.
Specificity
Human CASR. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Predicted Species
Turkey (100%), Xenopus (94%), Opossum (100%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
CASR
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry-Paraffin 1:10 - 1:500
Application Notes
ICC/IF usage is reported in scientific literature (PMID: 24217682).
Positive Control
Calcium-sensing R/CaSR Lysate (NBL1-08721)
Publications
Read Publication using
NLS1425 in the following applications:

Reactivity Notes

Gorilla, Gibbon, Marmoset. Predicted cross-reactivity based on sequence identity: Elephant (100%), Panda (100%), Platypus (100%).

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.1% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Calcium-sensing R/CaSR Antibody

  • calcium-sensing receptor
  • CAR
  • CaSR
  • EIG8
  • extracellular calcium-sensing receptor
  • FHH
  • FIH
  • GPRC2A
  • GPRC2AHHC
  • HHC1
  • hypocalciuric hypercalcemia 1
  • NSHPT
  • parathyroid Ca(2+)-sensing receptor 1
  • Parathyroid cell calcium-sensing receptor
  • PCaR1
  • PCAR1MGC138441

Background

CASR, a Calcium-Sensing Receptor, functions as a sensor in parathyroid and kidney to determine extracellular calcium concentration and to maintain calcium homeostasis. This receptor regulates both secretion of parathyroid hormone and excretion of urinary calcium. Mutations that inactivate CASR cause familial hypocalciuric hypercalcemia, which is also correlated with hyperparathyroidism. On the other hand, mutations that activate CASR cause autosomal dominant hypocalcemia. Hjalm et al. (2001) and Awata et al. (2001) have identified the binding of filamin-1 to the C-terminal tail of CASR, which may contribute to its localization in caveolae, link it to the actin-based cytoskeleton, and participate in CASR-mediated activation of MAPK. Multiple isoforms for CASR are produced by alternative splicing. CASR has been documented in bone marrow, brain, breast (mostly cancer), colon, kidney, parathyroid, skin, stomach, and thyroid. ESTs have been isolated from normal kidney and gallbladder, in addition to parathyroid cancer libraries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Applications: IHC-P

Publications for Calcium-sensing R/CaSR Antibody (NLS1425)(1)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: ICC/IF.


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(1)
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Positive Control Lysate(s)

Secondary Antibodies

 

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Bioinformatics

Gene Symbol CASR
Entrez