Gorilla, Gibbon, Marmoset. Predicted cross-reactivity based on sequence identity: Elephant (100%), Panda (100%), Platypus (100%).
Alternate Names for Calcium-sensing R/CaSR Antibody
extracellular calcium-sensing receptor
hypocalciuric hypercalcemia 1
parathyroid Ca(2+)-sensing receptor 1
Parathyroid cell calcium-sensing receptor
CASR, a Calcium-Sensing Receptor, functions as a sensor in parathyroid and kidney to determine extracellular calcium concentration and to maintain calcium homeostasis. This receptor regulates both secretion of parathyroid hormone and excretion of urinary calcium. Mutations that inactivate CASR cause familial hypocalciuric hypercalcemia, which is also correlated with hyperparathyroidism. On the other hand, mutations that activate CASR cause autosomal dominant hypocalcemia. Hjalm et al. (2001) and Awata et al. (2001) have identified the binding of filamin-1 to the C-terminal tail of CASR, which may contribute to its localization in caveolae, link it to the actin-based cytoskeleton, and participate in CASR-mediated activation of MAPK. Multiple isoforms for CASR are produced by alternative splicing. CASR has been documented in bone marrow, brain, breast (mostly cancer), colon, kidney, parathyroid, skin, stomach, and thyroid. ESTs have been isolated from normal kidney and gallbladder, in addition to parathyroid cancer libraries.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.