Calcium-sensing R/CaSR Antibody (611825) [Alexa Fluor® 350]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow
Clone
611825
Clonality
Monoclonal
Host
Mouse
Conjugate
Alexa Fluor 350

Calcium-sensing R/CaSR Antibody (611825) [Alexa Fluor® 350] Summary

Immunogen
Mouse myeloma cell line NS0-derived transfected with recombinant human Calcium-sensing R/CaSR protein
Tyr20-Lys601
Accession # P41180-1
Specificity
Detects human Calcium-sensing R/CaSR protein in direct ELISAs.
Source
N/A
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 0.25-1 ug/10^6 cells

Packaging, Storage & Formulations

Storage
Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.
Buffer
Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Calcium-sensing R/CaSR Antibody (611825) [Alexa Fluor® 350]

  • calcium-sensing receptor
  • CAR
  • CaSR
  • EIG8
  • extracellular calcium-sensing receptor
  • FHH
  • FIH
  • GPRC2A
  • GPRC2AHHC
  • HHC1
  • hypocalciuric hypercalcemia 1
  • NSHPT
  • parathyroid Ca(2+)-sensing receptor 1
  • Parathyroid cell calcium-sensing receptor
  • PCaR1
  • PCAR1MGC138441

Background

Calcium-sensing receptor (CasR) is a plasma membrane G-protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis (1). CasR is expressed in the parathyroid hormone-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule (2). Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism (3). The full length of CasR has a large extracellular N-terminal domain, a central region of 7 transmembrane domains, and a long intracellular C‑terminal domain. The amino acid 20-601 contains the extracellular domain with multiple glycosylation sites (4). Human CasR shares 96.1% and 96.5% aa sequence identity with mouse and rat CasR, respectively.
  1. Geng, Y. et al. (2016) Elife 5:e13662.
  2. Hendy, G. N. et al. (2000) Hum. Mutat. 16:281.
  3. Brown, E. M. et al. (1993) Nature 366:575.
  4. Garrett, J. E.et al. (1995) J. Biol. Chem. 270:12919.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 FAB9608U
Alexa Fluor 405 FAB9608V
Alexa Fluor 488 FAB9608G
Alexa Fluor 594 FAB9608T
Alexa Fluor 647 FAB9608R
Alexa Fluor 700 FAB9608N
Alexa Fluor 750 FAB9608S

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