Calcitonin Antibody (SP17)

Immunohistochemistry-Paraffin: Calcitonin Antibody (SP17) [NBP2-21752] - Human Thyroid Medullary Carcinoma.

Immunohistochemistry-Paraffin: Calcitonin Antibody (SP17) [NBP2-21752] - Human Thyroid Medullary Carcinoma.

Immunohistochemistry-Paraffin: Calcitonin Antibody (SP17) [NBP2-21752] - Human Pituitary.

Immunohistochemistry-Paraffin: Calcitonin Antibody (SP17) [NBP2-21752] - Human Lung Adenocarcinoma.

Product Discontinued

Calcitonin Antibody (SP17) Summary

• Additional Information: Recombinant Monoclonal Antibody.
• Immunogen: Synthetic human calcitonin 1-32 amino acid peptide.
• Localization: Cytoplasm
• Isotype: IgG
• Clonality: Monoclonal
• Host: Rabbit
• Gene: CALCA
• Purity: Tissue culture supernatant

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:100
  • Immunohistochemistry-Paraffin 1:100
• Theoretical MW: 15 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Tested in Human. Based on sequence identity cross reactivity is expected with Mouse and Rat.

Packaging, Storage & Formulations

• Storage: Store at 4C. Do not freeze.
• Buffer: TBS (pH 7.5) and 1.0% BSA
• Preservative: 0.1% Sodium Azide
• Purity: Tissue culture supernatant

Alternate Names for Calcitonin Antibody (SP17)

• ATP2B2plasma membrane calcium ATPase
• ATPase, Ca++ transporting, plasma membrane 4
• CALC1
• CALCA
• Calcitonin
• DKFZp686G08106
• DKFZp686M088
• EC 3.6.3
• EC 3.6.3.8
• Katacalcin
• Matrix-remodeling-associated protein 1
• matrix-remodelling associated 1
• MXRA1
• PCT
• Plasma membrane calcium ATPase isoform 4
• Plasma membrane calcium pump isoform 4
• plasma membrane calcium pump
• plasma membrane calcium-transporting ATPase 4
• PMCA4b
• PMCA4PMCA4x
• sarcolemmal calcium pump

Background

Calcitonin is a 32 amino acid peptide which can be demonstrated in C cells of the normal and hyperplastic thyroid. Staining for calcitonin may be used for the identification of a spectrum of C cell proliferative abnormalities ranging from C cell hyperplasia to invasive tumors. Staining for calcitonin in medullary carcinoma of the thyroid produces a fine granular pattern in the cytoplasm. Amyloid deposits within the tumor may also exhibit varying degrees of calcitonin activity.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Calcitonin Antibody (NBP2-21752)(1)

Publication using NBP2-21752

• Ghaffari-Tabrizi-Wizsy, N;Passegger, CA;Nebel, L;Krismer, F;Herzer-Schneidhofer, G;Schwach, G;Pfragner, R; The avian chorioallantoic membrane as an alternative tool to study medullary thyroid cancer Endocr Connect 2019-03-01 [PMID: 30913539] (IF/IHC, Human)

Bioinformatics

• Gene Symbol: CALCA