c-Maf Antibody (883926) [Alexa Fluor® 750]

• Reactivity: Hu
• Applications: WB, ICC/IF
• Clone: 883926
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 750

c-Maf Antibody (883926) [Alexa Fluor® 750] Summary

• Immunogen: E. coli-derived recombinant human c-Maf
  Met1-Phe372
  Accession # O75444
• Specificity: Detects human c-Maf in direct ELISA and Western Blot.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for c-Maf Antibody (883926) [Alexa Fluor® 750]

• Avian musculoaponeurotic fibrosarcoma (MAF) protooncogene
• CCA4
• c-maf proto-oncogene
• cMaf
• c-Maf
• MAF2
• MGC71685
• Proto-oncogene c-Maf
• T lymphocyte c-maf long form
• transcription factor Maf
• v-maf musculoaponeurotic fibrosarcoma (avian) oncogene homolog
• v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)
• V-maf musculoaponeurotic fibrosarcoma oncogene homolog

Background

c-Maf is an approximately 40 kDa transcriptional regulator that contains one bZIP domain. It can associate into homodimers and heterodimers with other basic leucine zipper transcription factors. c-Maf plays an important role in fetal erythropoiesis, lens development, mechanosensory neuron development, and the differentiation of chondrocytes and osteoblasts. In the pancreas, c-Maf promotes the transcription of glucagon in alpha cells and insulin in beta cells. In immune cells, it controls Th17 and Treg differentiation by regulating the transcription of IL-4, IL-12 p35, IL-21, IL-22, and GM-CSF. Human c-Maf shares 97% amino acid sequence identity with mouse and rat c-Maf. Alternative splicing of human c-Maf generates a long isoform with a 30 aa substitution for the C-terminal methionine.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.