BRM Recombinant Enzymes

• Reactivity: Hu
• Applications: NULL

BRM Recombinant Enzymes Summary

• Description: Human BRM (aa 1-1572) fused to 6xHis and FLAG-tag at the N-terminus. (Uniprot: P51531-2)
• Source: Sf 9 (baculovirus)
• Protein/Peptide Type: Recombinant Enzymes
• Gene: SMARCA2
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • N/A

Packaging, Storage & Formulations

• Storage: Store at -80C. Avoid freeze-thaw cycles.
• Buffer: 20 mM Tris-HCl, pH 7.9, 150 mM NaCl, 15% glycerol, 2 mM MgCl2, 0.2 mM EDTA, 1 mM DTT, 10 mM beta-glycerophospate, 0.4 mM PMSF, 1 mM benzamidine and 0.4 mg/ml recombinant human insulin
• Preservative: No Preservative
• Purity: Immunogen affinity purified

Alternate Names for BRM Recombinant Enzymes

• ATP-dependent helicase SMARCA2
• BAF190B
• BRG1-associated factor 190B
• BRM
• BRMFLJ36757
• EC 3.6.1
• EC 3.6.4.-
• global transcription activator homologous sequence
• hBRM
• hBRMMGC74511
• hSNF2a
• probable global transcription activator SNF2L2
• Protein brahma homolog
• SMARCA2
• SNF2
• SNF2/SWI2-like protein 2
• SNF2A
• SNF2-alpha
• SNF2L2
• SNF2L2BAF190
• SNF2LA
• SNF2-like 2
• Sth1p
• subfamily a, member 2
• sucrose nonfermenting 2-like protein 2
• SWI/SNF related, matrix associated, actin dependent regulator of chromatin
• SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a2
• SWI/SNF-related matrix-associated actin-dependent regulator of chromatinsubfamily A member 2
• SWI2

Background

BRM is encoded by this gene is a member of the SWI/SNF family of proteins and is highly similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. Two transcript variants encoding different isoforms have been found for this gene, which contains a trinucleotide repeat (CAG) length polymorphism.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

Bioinformatics

• Gene Symbol: SMARCA2