BRM Products

Description

Chimera RNA interference (chimera RNAi) is process by which small interfering RNA/DNA chimera triggers the destruction of mRNA for the original gene.  The discovery work, design, and application of chimera RNAi has been pioneered by Professor Kaoru Saigo and Dr. Kumiko Ui-Tei at the University of Tokyo.  Chimera RNAi has many advantages over the conventional siRNAs.  First, it has been demonstrated to have reliable knock-down for over 10,000 human genes.  Because the human genome is composed of an intricate, genetic network, chimera RNAi's unique design has successfully obviated the off-target effects including microRNA-based influence.  Another advantage of the chimera RNAi technology is its effectiveness at low concentrations (0.5nM to 5nM); only mRNA is destroyed so genomic genes are not affected.  Finally, having both the sense and anti-sense strands consisting RNA/DNA chimera, it offers much greater compound stability for streamlining in vitro and in vivo assays and applications while minimizing interferon induction and other adverse reactions.

Bioinformatics

Product By Gene ID

6595

Alternate Names

ATP-dependent helicase SMARCA2 BAF190B BRG1-associated factor 190B BRM BRMFLJ36757 EC 3.6.1 EC 3.6.4.- global transcription activator homologous sequence hBRM hBRMMGC74511 hSNF2a probable global transcription activator SNF2L2 Protein brahma homolog SMARCA2 SNF2 SNF2/SWI2-like protein 2 SNF2A SNF2-alpha SNF2L2 SNF2L2BAF190 SNF2LA SNF2-like 2 Sth1p subfamily a, member 2 sucrose nonfermenting 2-like protein 2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a2 SWI/SNF-related matrix-associated actin-dependent regulator of chromatinsubfamily A member 2 SWI2