Recombinant Human beta-Synuclein Active, Pre-formed Fibrils, (Type 1) Protein

Electron Microscopy: Recombinant Human beta-Synuclein Active, Pre-formed Fibrils, (Type 1) Protein [NBP3-14777] - TEM of Active Human Recombinant Beta Synuclein Protein Pre-formed Fibrils (Type 1) (NBP3-14777)

• Reactivity: Hu
• Applications: WB, Func, MS, PAGE

Recombinant Human beta-Synuclein Active, Pre-formed Fibrils, (Type 1) Protein Summary

• Description: A full length recombinant protein of Human beta-Synuclein
  
  

  Source: E. coli

  Uniprot ID: Q16143

• Localization: Cytoplasm
• Preparation Method: Ion-exchange Purified
• Protein/Peptide Type: Recombinant Protein
• Gene: SNCB
• Purity: >95%, by SDS-PAGE

Applications/Dilutions

• Dilutions:
  • Electron Microscopy
  • In vitro assay
  • In vivo assay
  • SDS-Page
  • Western Blot

Packaging, Storage & Formulations

• Storage: Store at -80C. Avoid freeze-thaw cycles.
• Buffer: PBS pH 7.4
• Preservative: No Preservative
• Purity: >95%, by SDS-PAGE

Notes

Please note that the 200ug and 500ug sizes are sent in 2x100ug and 5x100ug vials, respectively

Alternate Names for Recombinant Human beta-Synuclein Active, Pre-formed Fibrils, (Type 1) Protein

• beta-Synuclein
• SNCB
• synuclein, beta
• Synuclein-beta

Background

Alpha synuclein is an abundant 140 amino acid neuronal protein, expressed primarily at presynaptic terminals in the central nervous system. Alpha synuclein has been associated with several neurodegenerative diseases. A point mutation in the gene coding for the alpha-synuclein protein was the first discovery linking this protein to a rare familial form of Parkinson's disease (PD). Subsequently, other mutations in the alpha-synuclein gene have been identified in familial PD. The aggregated proteinaceous inclusions called Lewy bodies found in PD and cortical Lewy body dementia (LBD) were discovered to be predominantly alpha-synuclein. Aberrant aggregation of alpha-synuclein has been detected in an increasing number of neurodegenerative diseases, collectively known as synucleopathies. Alpha-synuclein exists physiologically in both soluble and membrane-bound states, in unstructured and alpha-helical conformations, respectively. The physiological function of alpha-synuclein appears to require its translocation between these subcellular compartments and interconversion between the 2 conformations. Abnormal processing of alpha-synuclein is predicted to lead to pathological changes in its binding properties and function (1).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

Bioinformatics

• Gene Symbol: SNCB