beta-Synuclein Products

Antibodies
beta-Synuclein Antibody
beta-Synuclein Antibody
NBP1-90342
Species: Hu, Mu, Rt
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
beta-Synuclein Antibody [Unco ...
beta-Synuclein Antibody [Unconjuga...
AF5528
Species: Hu
Applications: WB, IHC
Host: Sheep Polyclonal
Formulation Catalog # Availability Price  
beta-Synuclein Antibody (5165 ...
beta-Synuclein Antibody (516505) [...
MAB5528
Species: Hu
Applications: WB, IHC
Host: Mouse Monoclonal
Formulation Catalog # Availability Price  
Lysates
beta-Synuclein Overexpression ...
beta-Synuclein Overexpression Lysate
NBL1-16276
Species: Hu
Applications: WB
beta-Synuclein Overexpression ...
beta-Synuclein Overexpression Lysate
NBL1-16275
Species: Hu
Applications: WB
Proteins
Recombinant Human beta-Synucl ...
Recombinant Human beta-Synuclein P...
NBC1-18328
Species: Hu
Applications: PAGE
beta-Synuclein Recombinant Pr ...
beta-Synuclein Recombinant Protein...
NBP1-90342PEP
Species: Hu
Applications: AC

Description

Alpha synuclein is an abundant 140 amino acid neuronal protein, expressed primarily at presynaptic terminals in the central nervous system. Alpha synuclein has been associated with several neurodegenerative diseases. A point mutation in the gene coding for the alpha-synuclein protein was the first discovery linking this protein to a rare familial form of Parkinson's disease (PD). Subsequently, other mutations in the alpha-synuclein gene have been identified in familial PD. The aggregated proteinaceous inclusions called Lewy bodies found in PD and cortical Lewy body dementia (LBD) were discovered to be predominantly alpha-synuclein. Aberrant aggregation of alpha-synuclein has been detected in an increasing number of neurodegenerative diseases, collectively known as synucleopathies. Alpha-synuclein exists physiologically in both soluble and membrane-bound states, in unstructured and alpha-helical conformations, respectively. The physiological function of alpha-synuclein appears to require its translocation between these subcellular compartments and interconversion between the 2 conformations. Abnormal processing of alpha-synuclein is predicted to lead to pathological changes in its binding properties and function (1).

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Human
Human
Product By Gene ID 6620
Alternate Names
  • beta-synuclein
  • synuclein, beta

Research Areas for beta-Synuclein

Find related products by research area and learn more about each of the different research areas below.

Alzheimers Research
Neuroscience

PTMs for beta-Synuclein

Learn more about PTMs related to beta-Synuclein.

Phosphorylation
Cleavage
Nitration
Biotinylation
Oxidation

Bioinformatics Tool for beta-Synuclein

Discover related pathways, diseases and genes to beta-Synuclein. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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