beta-Synuclein Antibody

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Product Details

Summary
Product Discontinued
View other related beta-Synuclein Primary Antibodies

Order Details


    • Catalog Number
      NB100-91982
    • Availability
      Product Discontinued

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beta-Synuclein Antibody Summary

Immunogen
Synthetic peptide, corresponding to amino acids 82-140 of Human Synuclein-beta.
Clonality
Polyclonal
Host
Rabbit
Gene
SNCB
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:1000
  • Immunocytochemistry/Immunofluorescence 1:50-1:200
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:50-1:200
Application Notes
Western blot (WB) analysis of beta-Synuclein Antibody (S118) pAb in extracts from HeLa cells.
Immunohistochemistry (IHC) analyzes of beta-Synuclein Antibody (S118) pAb in paraffin-embedded human brain tissue.
Theoretical MW
14 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

This antibody is reactive against Human, Mouse, Rat.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2)
Preservative
0.05% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for beta-Synuclein Antibody

  • beta-Synuclein
  • SNCB
  • synuclein, beta
  • Synuclein-beta

Background

The synuclein family members, including alpha-synuclein (also designated NACP for non-beta amyloid component) and beta-synuclein, are predominantly expressed in the brain and are speculated to be involved in synaptic regulation and neuronal plasticity. alpha-synuclein is localized to neuronal cell bodies and synapses. alpha-synuclein was first identified as a component of Alzheimer's disease amyloid plaques. Abnormal platelet function in Alzheimer's disease has been demonstrated. During megakaryocytic differentiation alpha-synuclein was found to be upregulated, while beta-synuclein is downregulated, indicating that coordinate expression of synucleins may be important during hematopoetic cell differentiation. A mutant form of alpha-synuclein has been found in patients with early onset Parkinson's disease.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol SNCB
Entrez