beta I Tubulin Antibody (86CT4.4.4)

Product Discontinued

beta I Tubulin Antibody (86CT4.4.4) Summary

• Immunogen: This monoclonal antibody is generated from mice immunized with a recombinant protein human TBB1.
• Localization: Cellular Location Cytoplasm, cytoskeleton. Tissue Location Hematopoietic cell-specific. Major isotype in leukocytes, where it represents 50% of all beta-tubulins
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: TUBB1
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence 1:10 - 1:50
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 1:10 - 1:50
  • Western Blot 1:100 - 1:500
• Theoretical MW: 50.327 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Additional Mouse on Mouse blocking steps may be required for IHC and ICC experiments. Please contact Technical Support for more information.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.09% Sodium Azide
• Concentration: 1.7 mg/ml
• Purity: Protein G purified

Alternate Names for beta I Tubulin Antibody (86CT4.4.4)

• beta tubulin 1, class VI
• betaI Tubulin
• beta-I Tubulin
• dJ543J19.4
• TUBB1
• tubulin beta-1 chain
• tubulin, beta 1

Background

This gene encodes a member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is specifically expressed in platelets and megakaryocytes and may be involved in proplatelet production and platelet release. A mutations in this gene is associated with autosomal dominant macrothrombocytopenia. Two pseudogenes of this gene are found on chromosome Y.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: TUBB1
• Uniprot:
  • Q9H4B7()
  • Q9H4B7()