beta 2-Microglobulin Antibody (B2M/961) [Janelia Fluor® 646]

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Product Details

Summary
Reactivity Hu, PmSpecies Glossary
Applications Flow, IHC, IHC-P, ICC/IF
Clone
B2M/961
Clonality
Monoclonal
Host
Mouse
Conjugate
Janelia Fluor 646

Order Details

beta 2-Microglobulin Antibody (B2M/961) [Janelia Fluor® 646] Summary

Immunogen
Full length recombinant human B2M protein
Localization
Cell Surface and Extracellular (Secreted)
Marker
Renal Failure & Tumor Marker
Specificity
Recognizes a protein of 12kDa, identified as beta-2 microglobulin. Major histocompatibility complex (MHC) class 1 molecules bind to antigens for presentation on the surface of cells. The proteasome is responsible for producing these antigens from the components of foreign pathogens. MHC class 1 molecules consist of an alpha heavy chain that contains three subdomains (alpha1, alpha2, alpha3) and a non-covalent associating light chain, known as beta-2-Microglobulin. beta-2-Microglobulin associates with the alpha3 subdomain of the alpha heavy chain and forms an immunoglobulin domain-like structure that mediates proper folding and expression of MHC class 1 molecules. The alpha1 and alpha2 domains of the alpha heavy chain form the peptide antigen-binding cleft. Mutations in the beta-2-Microglobulin gene can enhance the progression of malignant melanoma phenotypes.
Isotype
IgG2b Kappa
Clonality
Monoclonal
Host
Mouse
Gene
B2M
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Immunofluorescence
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for beta 2-Microglobulin Antibody (B2M/961) [Janelia Fluor® 646]

  • B2M
  • beta 2Microglobulin
  • beta 2-Microglobulin
  • beta chain of MHC class I molecules
  • beta-2-microglobin
  • beta-2-microglobulin

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 NBP2-47704AF350
Alexa Fluor 405 NBP2-47704AF405
Alexa Fluor 488 NBP2-47704AF488
Alexa Fluor 532 NBP2-47704AF532
Alexa Fluor 594 NBP2-47704AF594
Alexa Fluor 647 NBP2-47704AF647
Alexa Fluor 700 NBP2-47704AF700
Alexa Fluor 750 NBP2-47704AF750
Allophycocyanin NBP2-47704APC
Allophycocyanin/Cy7 NBP2-47704APCCY7
Biotin NBP2-47704B
DyLight 350 NBP2-47704UV
DyLight 405 NBP2-47704V
DyLight 488 NBP2-47704G
DyLight 550 NBP2-47704R
DyLight 594 NBP2-47704DL594
DyLight 650 NBP2-47704C
DyLight 680 NBP2-47704FR
DyLight 755 NBP2-47704IR
FITC NBP2-47704F
HRP NBP2-47704H
Janelia Fluor 549 NBP2-47704JF549
Janelia Fluor 646 NBP2-47704JF646
PE NBP2-47704PE
PE/Atto594 NBP2-47704PEATT594
PE/Cy5.5 NBP2-47704PECY55
PE/Cy7 NBP2-47704PECY7
PerCP NBP2-47704PCP

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Bioinformatics Tool for beta 2-Microglobulin Antibody (NBP2-47704JF646)

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Bioinformatics

Gene Symbol B2M