beta-1 Adrenergic R/ADRB1 Antibody (2203D) [Biotin]

• Reactivity: Hu
• Applications: WB
• Clone: 2203D
• Clonality: Monoclonal
• Host: Rabbit
• Conjugate: Biotin

beta-1 Adrenergic R/ADRB1 Antibody (2203D) [Biotin] Summary

• Additional Information: Recombinant Monoclonal Antibody.
• Immunogen: Synthetic peptide containing human beta ‑1 Adrenergic R/ADRB1
  Accession # P08588
• Specificity: Detects human beta ‑1 Adrenergic R/ADRB1 in direct ELISAs.
• Isotype: IgG
• Clonality: Monoclonal
• Host: Rabbit
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from hybridoma culture supernatant

Alternate Names for beta-1 Adrenergic R/ADRB1 Antibody (2203D) [Biotin]

• ADRB1
• ADRB1R
• ADRB1RRHR
• adrenergic, beta-1-, receptor
• B1AR
• beta-1 Adrenergic R
• beta-1 adrenergic receptor
• beta1 AdrenergicR
• beta-1 AdrenergicR
• Beta-1 adrenoceptor
• Beta-1 adrenoreceptor
• BETA1AR

Background

Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.