BCAP31 Antibody (CC-4)

Western Blot: BCAP31 Antibody (CC-4) [NB100-74365] - Analysis of BAP31.

Immunohistochemistry-Frozen: BCAP31 Antibody (CC-4) [NB100-74365] - Staining in baboon pituitary gland.

Product Discontinued

BCAP31 Antibody (CC-4) Summary

• Immunogen: Amino acid residues 123-229 of human BAP31.
• Specificity: BAP31 (CC-4)
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Rat
• Gene: BCAP31
• Purity: Unpurified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry 1:100
  • Immunocytochemistry/ Immunofluorescence 1:1000
  • Immunohistochemistry
  • Immunohistochemistry-Frozen 1:10 - 1:500
  • Immunoprecipitation 1:10 - 1:500
  • Western Blot 1:1500 - 1:6000
• Application Notes: WB: Detects a 28-kDa protein representing human BAP31.
• Control:

  BCAP31 Overexpression Lysate

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Ascites
• Preservative: 0.02% Sodium Azide
• Purity: Unpurified

Alternate Names for BCAP31 Antibody (CC-4)

• 6C6-Ag
• BAP31
• Bap31,6C6-AG
• BAP31DXS1357ECDM
• BCAP31
• B-cell receptor-associated protein 31
• BCR-associated protein 31
• BCR-associated protein Bap31,6C6-AG tumor-associated antigen
• p28 Bap31,6C6-Ag
• p28
• Protein CDM

Background

BAP31 (B Cell Receptor Associated Protein, 28 kDa) is a multiple membrane spanning protein of the endoplasmic reticulum. It has been shown to form both homo and hetero oligomers with the closely related BAP29, and is a potential apoptotic regulator as a predicted BCL2/BCLXL associated protein. In the C terminal domain of BAP31, there are two identical recognition sites for initiator Caspases 1 and 8 of the programmed death cascade. It is hypothesized that BAP31 plays a role in the transport of selected proteins to the Golgi apparatus. BAP31 has also been shown to control expression of CFTR (cystic fibrosis transmembrane conductance regulator). It is believed that interference with the expression or function of BAP31 in epithelial cells may be a way to circumvent the chloride channel defect in cystic fibrosis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: BCAP31
• Entrez:
  • 10134(Human)