BCAP31 Antibody (CC-1)

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Product Details

Summary
Reactivity Hu, Bv, Ha, Pm, Mu(-), Rt(-)Species Glossary
Applications WB, ELISA, ICC/IF, IHC, IHC-Fr, IP
Clone
CC-1
Clonality
Monoclonal
Host
Rat
Conjugate
Unconjugated
Concentration
0.5 mg/ml

Order Details

BCAP31 Antibody (CC-1) Summary

Immunogen
Solubilized membranes of the IMR-32 human neuroblastoma cell line.
Specificity
Recognizes an epitope (aa 230-246) encompassing a caspase recognition site and the ER-homing motif (KKEE), present at the C-terminus of human, primate, Bovine and Hamster BAP31.
Isotype
IgG2a
Clonality
Monoclonal
Host
Rat
Gene
BCAP31
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:1000-1:6000
  • ELISA 1:100-1:2000
  • Immunocytochemistry/Immunofluorescence 1:1000-1:10000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:1000-1:10000
  • Immunoprecipitation 1:10-1:500
Application Notes
This antibody is useful in ELISA (capture) and Immunoprecipitation. Works on endogenous for Immunocytochemistry, Immunohistochemistry-Frozen and Western Blot.
Publications
Read Publications using NBP1-97439.

Reactivity Notes

Human, Primate, Bovine and Hamster. Does not recognize mouse and rat BAP31.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
0.5 mg/ml
Purity
Protein G purified

Alternate Names for BCAP31 Antibody (CC-1)

  • 6C6-Ag
  • BAP31
  • Bap31,6C6-AG
  • BAP31DXS1357ECDM
  • BCAP31
  • B-cell receptor-associated protein 31
  • BCR-associated protein 31
  • BCR-associated protein Bap31,6C6-AG tumor-associated antigen
  • p28 Bap31,6C6-Ag
  • p28
  • Protein CDM

Background

BAP31 (B cell receptor-associated protein 31) is an integral protein of the ER membrane that forms a large hetero-oligomeric complex with the related BAP29. The cytosolic domain of BAP31 contains two identical caspase recognition sites that are preferentially cleaved by initiator caspases, including caspase-8. After activation of cell surface death receptors, human BAP31 is cleaved into a membrane-embedded fragment called p20, which induces apoptosis when expressed ectopically. The p20 fragment can mediate Ca2+-dependent apoptotic cross-talk between the ER and mitochondria, stimulating cytochrome c release. In addition to its role in apoptosis, BAP31 is a component of the ER quality control compartment and functions as a cargo receptor for ER export of transmembrane proteins such as cellubrevin, MHC class I molecules, and cytochrome P450 2C2.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for BCAP31 Antibody (NBP1-97439)(3)

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol BCAP31
Entrez