BAT3/BAG6 Antibody

Immunohistochemistry-Paraffin: BAT3/BAG6 Antibody [NBP1-36941] - Staining of Human Spleen. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

• Reactivity: Hu, Mu, Rt, Po, Bv, Ca
• Applications: ELISA, IHC
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Unconjugated
• Concentration: 0.5 mg/ml

BAT3/BAG6 Antibody Summary

• Description: Novus Biologicals Goat BAT3/BAG6 Antibody (NBP1-36941) is a polyclonal antibody validated for use in IHC and ELISA. Anti-BAT3/BAG6 Antibody: Cited in 1 publication. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: Peptide with sequence C-PETNAPNHPSPAEY corresponding to internal region according to NP_542433.1.
• Epitope: internal region
• Specificity: This antibody is expected to recognize both reported isoforms (NP_004630.3; NP_542433.1). Reported variants representing identical protein: NP_542434.1, NP_001092004.1, NP_542433.1 (isoform b).
• Predicted Species: Mouse (100%), Rat (100%), Porcine (100%), Bovine (100%), Canine (100%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: BAG6
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 3 - 5 ug/ml
  • Immunohistochemistry-Paraffin 1:10-1:500
  • Peptide ELISA Detection limit 1:128000
• Application Notes: WB: Preliminary experiments in human brain (frontal cortex) and human ovary lysates gave no specific signal but low background. IHC-P: Human spleen shows nucleoli staining in splenocytes.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for BAT3/BAG6 Antibody

• BAG6
• BAT3
• BAT3HLA-B associated transcript-3
• BCL2-associated athanogene 6BAG-6
• D6S52E
• D6S52EHLA-B-associated transcript 3
• G3BAG family molecular chaperone regulator 6
• HLA-B associated transcript 3
• large proline-rich protein BAT3
• Protein G3
• Protein Scythe
• Scythe

Background

BAT3 was first characterized as part of a cluster of genes located within the human major histocompatibility complex class III region. This gene encodes a nuclear protein that is cleaved by caspase 3 and is implicated in the control of apoptosis. In addition, the protein forms a complex with E1A binding protein p300 and is required for the acetylation of p53 in response to DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for BAT3/BAG6 Antibody (NBP1-36941)(1)

Publication using NBP1-36941

• Annunziata CM, Kleinberg L, Davidson B et al. BAG-4/SODD and associated antiapoptotic proteins are linked to aggressiveness of epithelial ovarian cancer. Clin Cancer Res 2007-11-15 [PMID: 18006758]

Bioinformatics

• Gene Symbol: BAG6
• Entrez:
  • 7917(Human)
  • 224727(Mouse)
  • 94342(Rat)
• Uniprot:
  • NP_004630.3(Human)