Recombinant Human BAFFR/TNFRSF13C Protein

SDS-Page: Recombinant Human BAFFR/TNFRSF13C Protein [NBP2-34879]

• Reactivity: Hu
• Applications: PAGE, Bioactivity
• Format: Carrier-Free
• Concentration: LYOPH

Recombinant Human BAFFR/TNFRSF13C Protein Summary

• Description: A single non-glycosylated polypeptide chain containing 76 amino acids corresponding to BAFFR/TNFRSF13C Source: E. coli

  Uniprot ID: Q96RJ3

  Amino Acid Sequence: MRRGPRSLRG RDAPAPTPCV PAECFDLLVR HCVACGLLRT PRPKPAGASS PAPRTALQPQ ESVGAGAGEA ALPLPG

• Details of Functionality: BAFF Receptor protein is fully biologically active when compared to standard. The ED50 as determined by its ability to block BAFF induced mouse splenocyte survival is 1.0-5.0 ug/ml in the presence of 1.0 ug/ml of rHuBAFF.
• Source: E. coli
• Protein/Peptide Type: Recombinant Protein
• Gene: TNFRSF13C
• Purity: >95%, by reducing SDS-PAGE
• Endotoxin Note: Less than 1 EU/ug of BAFFR/TNFRSF13C as determined by LAL method.

Applications/Dilutions

• Dilutions:
  • Bioactivity
  • SDS-Page
• Theoretical MW: 7.8 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at -20 to -70C as supplied. After reconstitution, store at 2 to 8C for 1 month and at -20 to -70C for long term storage. Avoid repeated freeze-thaw cycles.
• Buffer: Lyophilized from a 0.2 um filtered concentrated solution in 20 mM PB, pH 8.0, 500 mM NaCl.
• Preservative: No Preservative
• Concentration: LYOPH
• Purity: >95%, by reducing SDS-PAGE
• Reconstitution Instructions: Recommended to centrifuge prior to opening. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0mg/mL.

Alternate Names for Recombinant Human BAFFR/TNFRSF13C Protein

• BAFF R
• BAFF Receptor/TNFRSF13C
• BAFFR
• BAFFR;BAFF-R;BROMIX;CD268;CVID4;prolixin;Tumor necrosis factor receptor superfamily member 13C
• BR3
• CD268
• TNFRSF13C

Background

B Cell Activating Factor Receptor (BAFF-R), also named tumor necrosis factor receptor superfamily member 13C, is a member of the TNFR superfamily. It is highly expressed in spleen, lymph node, and resting B cells and to some extent in activated B cells, resting CD4+ cells and peripheral blood leukocytes. BAFF receptor is a type III transmembrane protein containing a single extracellular phenylalanine-rich domain and binds with high specificity to BAFF (TNFSF13B). It enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. BAFF receptor/BAFF signaling plays a critical role in B cell survival and maturation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

Bioinformatics

• Gene Symbol: TNFRSF13C
• Uniprot:
  • Q96RJ3()
  • Q96RJ3()
  • Q96RJ3()