Human BACE-2 ELISA Kit (Colorimetric)

ELISA: Human BACE-2 ELISA Kit (Colorimetric) [NBP2-66745] - Samples were spiked with high concentrations of Human BACE-2 and diluted with Reference Standard & Sample Diluent to produce samples with values within the range of the assay.

ELISA: Human BACE-2 ELISA Kit (Colorimetric) [NBP2-66745] - Standard Curve Reference

• Reactivity: Hu
• Applications: ELISA
• Suitable Sample Type: Serum, plasma and other biological fluids
• Standard Curve Range: 0.16 - 10 ng/mL
• Sensitivity: 0.10 ng/mL

Human BACE-2 ELISA Kit (Colorimetric) Summary

• Specificity: This kit recognizes Human BACE2 in samples. No significant cross-reactivity or interference between Human BACE2 and analogues was observed.
• Standard Curve Range: 0.16 - 10 ng/mL
• Sensitivity: 0.10 ng/mL
• Assay Type: Sandwich-ELISA
• Inter-Assay: CV% < 5%
• Intra-Assay: CV% < 5.52%
• Spike Recovery: 86-112%
• Sample Volume: 100 uL
• Kit Type: ELISA Kit (Colorimetric)
• Gene: BACE2

Applications/Dilutions

• Dilutions:
  • ELISA

Packaging, Storage & Formulations

• Storage: Storage of components varies. See protocol for specific instructions.

Alternate Names for Human BACE-2 ELISA Kit (Colorimetric)

• AEPLC
• Asp 1
• ASP1
• ASP21
• Aspartic-like protease 56 kDa
• Aspartyl protease 1
• BACE2
• BACE-2
• beta secretase 2
• beta-secretase 2
• beta-site amyloid beta A4 precursor protein-cleaving enzyme 2
• Beta-site amyloid precursor protein cleaving enzyme 2
• Beta-site APP cleaving enzyme 2
• beta-site APP-cleaving enzyme 2
• beta-site APP-cleaving enzyme 2, EC 3.4.2310ALP5656 kDa aspartic-like protease
• CEAP1
• Down region aspartic protease
• Down syndrome region aspartic protease
• DRAPBAE2
• EC 3.4.23
• EC 3.4.23.45
• memapsin-1
• Membrane-associated aspartic protease 1
• theta-secretase
• transmembrane aspartic proteinase Asp1

Background

BACE2 (Memapsin 1) is a membrane-bound aspartic protease that is highly homologous with BACE1 (Memapsin 2). While BACE1 processes the amyloid precursor protein (APP) at a key step in generating the beta-amyloid peptide and presumably causes Alzheimer's disease (AD), BACE2 has not been demonstrated to be directly involved in APP processing, and its physiological functions remain to be determined. In vivo, BACE2 is expressed as a precursor protein containing pre-, pro-, protease, transmembrane, and cytosolic domains/peptides.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. ELISA Kits are guaranteed for 6 months from date of receipt.

Bioinformatics

• Gene Symbol: BACE2