B7-2/CD86 Antibody (GL1)

Images

 
Flow Cytometry: B7-2/CD86 Antibody (GL1) [NBP2-30148] - Staining of 3-day LPS-stimulated BALB/c splenocytes with 0.25 ug of Rat IgG2a kappa Isotype Control Purified (open histogram) or 0.25 ug of Purified Anti-Mouse ...read more

Product Details

Summary
Reactivity MuSpecies Glossary
Applications Flow
Clone
GL1
Clonality
Monoclonal
Host
Rat
Conjugate
Unconjugated
Concentration
0.5 mg/ml
   

Biological Strategies

     

B7-2/CD86 Antibody (GL1) Summary

Immunogen
CD86 protein
Marker
DC Maturation Marker
Isotype
IgG2a Kappa
Clonality
Monoclonal
Host
Rat
Gene
CD86
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 0.5-2 ug/10^6 cells
Publications
Read Publication using
NBP2-30148 in the following applications:

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
Sterile - filtered PBS
Preservative
No Preservative
Concentration
0.5 mg/ml
Purity
Protein G purified

Alternate Names for B7-2/CD86 Antibody (GL1)

  • Activation B7-2 antigen
  • B70
  • B7-2 antigen
  • B72
  • B7-2
  • B-lymphocyte activation antigen B7-2
  • BU63
  • CD28 antigen ligand 2
  • CD28LG2B7-2 antigen)
  • CD86 antigen
  • CD86 molecule
  • CD86
  • CTLA-4 counter-receptor B7.2
  • FUN-1
  • LAB72
  • MGC34413
  • T-lymphocyte activation antigen CD86

Background

CD86/B7-2 as a costimulatory molecule plays a critical role in the activation of naive T-cells and subsequent differentiation by interacting with CD28 and/or CTLA present on T cells. T-cell activation requires both antigen presentation to the T-cell receptor and a second signal mediated by CD80 and CD86 on antigen-presenting cells and CD28 and CTLA-4 on the T cell. CD86 is constitutively expressed on APCs and B cells and under specific conditions on other activated cells. Certain toll like receptor (TLR) ligands, such as LPS (for TLR4) and Poly I:C (for TLR3) have been shown to enhance expression of CD40, CD80, CD86, CD83 and HLA-DR in human papillomavirus (HPV) type 11 E7 loaded monocyte-derived dendritic cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for B7-2/CD86 Antibody (NBP2-30148)(1)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: FLOW.


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FAQs for B7-2/CD86 Antibody (NBP2-30148) (0)

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Secondary Antibodies

 

Isotype Controls

Additional B7-2/CD86 Products

Bioinformatics Tool for B7-2/CD86 Antibody (NBP2-30148)

Discover related pathways, diseases and genes to B7-2/CD86 Antibody (NBP2-30148). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Diseases for B7-2/CD86 Antibody (NBP2-30148)

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Pathways for B7-2/CD86 Antibody (NBP2-30148)

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PTMs for B7-2/CD86 Antibody (NBP2-30148)

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Research Areas for B7-2/CD86 Antibody (NBP2-30148)

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Blogs on B7-2/CD86.

CD86 - I work in tandem with CD80
CD86 belongs to the immunoglobulin superfamily of proteins that drive innate and adaptive immune responses. It is an 80kD co-stimulatory molecule for the priming and activation of naive and memory T-cells, respectively. CD86 is expressed on activated...  Read full blog post.

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Bioinformatics

Gene Symbol CD86
Entrez