Hu, Mu, RtApplications:
WB, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, IP, KOHost:
WB, Flow, B/N, CyTOF-ready, KOHost:
WB, IHC, B/N, KOHost:
Host: Rabbit Monoclonal
Host: Mouse Monoclonal
B7-2 (CD86) is an important costimulatory molecule for the priming and activation of naive and memory T cells, respectively. Soluble CD86 is produced by resting monocytes and results from an alternatively spliced transcript (CD86deltaTM) characterized by deletion of the transmembrane domain (1). Engagement of CD28 with B7-1 and B7-2 ligands on antigen-presenting cells (APCs) provides a stimulatory signal for T-cell activation, whereas subsequent engagement of CTLA-4 with these same ligands results in attenuation of the response. Given their central function in immune modulation, CTLA-4- and CD28-associated signaling pathways are primary therapeutic targets for preventing autoimmune disease, graft versus host disease, graft rejection and promoting tumor immunity (2). It has also been shown that on B cells and macrophages, heat shock proteins GroES and GroEL both stimulated the expression of B7-2 (3)
|Product By Gene ID
- CD86 antigen
- T-lymphocyte activation antigen CD86
- CTLA-4 counter-receptor B7.2
- CD28 antigen ligand 2
- B7-2 antigen
- B-lymphocyte activation antigen B7-2
- Activation B7-2 antigen
- CD28LG2B7-2 antigen)
- CD86 molecule
Bioinformatics Tool for B7-2/CD86
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|CD86 - I work in tandem with CD80
CD86 belongs to the immunoglobulin superfamily of proteins that drive innate and adaptive immune responses. It is an 80kD co-stimulatory molecule for the priming and activation of naive and memory T-cells, respectively. CD86 is expressed on activated... Read more.