B7-2/CD86 Products

Description

B7-2 (CD86) is an important costimulatory molecule for the priming and activation of naive and memory T cells, respectively. Soluble CD86 is produced by resting monocytes and results from an alternatively spliced transcript (CD86deltaTM) characterized by deletion of the transmembrane domain (1). Engagement of CD28 with B7-1 and B7-2 ligands on antigen-presenting cells (APCs) provides a stimulatory signal for T-cell activation, whereas subsequent engagement of CTLA-4 with these same ligands results in attenuation of the response. Given their central function in immune modulation, CTLA-4- and CD28-associated signaling pathways are primary therapeutic targets for preventing autoimmune disease, graft versus host disease, graft rejection and promoting tumor immunity (2). It has also been shown that on B cells and macrophages, heat shock proteins GroES and GroEL both stimulated the expression of B7-2 (3)

Bioinformatics

Entrez	942 Human 12524 Mouse 56822 Rat
Uniprot	NP_008820 Human P42081 Human AAH40261 Human AAH40261.1 Human
Product By Gene ID	942
Alternate Names	B7-2 CD86 antigen LAB72 T-lymphocyte activation antigen CD86 CTLA-4 counter-receptor B7.2 CD28 antigen ligand 2 FUN-1 B7-2 antigen BU63 B-lymphocyte activation antigen B7-2 B70 Activation B7-2 antigen CD28LG2B7-2 antigen) MGC34413 CD86 molecule

Diseases related to B7-2/CD86

Discover more about diseases related to B7-2/CD86.

Neoplasms
Malignant Neoplasms
Inflammation
Autoimmune Reaction
Tissue Adhesions
Autoimmune Diseases
Leukemia
Decreased Immunologic Activity [pe]
Autoimmunity
Carcinoma
Infective Disorder
Asthma
Hiv Infections
Arthritis
Melanoma
Hepatitis
Lymphoma
Immunologic Deficiency Syndromes
Malignant Paraganglionic Neoplasm
Myeloid Leukemia

Pathways for B7-2/CD86

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Immune Response
Secretion
Cell Activation
Cell Proliferation
Cytokine Production
T Cell Activation
T Cell Proliferation
Pathogenesis
Sensitization
Cell Maturation
Cell Differentiation
Phagocytosis
Hypersensitivity
Cytokine Secretion
Endocytosis
Cell Death
Localization
Inflammatory Response
Lymphocyte Proliferation
Cell Development

Research Areas for B7-2/CD86

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Adaptive Immunity
Cell Cycle and Replication
Dendritic Cell Markers
Diabetes Research
Immunology

PTMs for B7-2/CD86

Learn more about PTMs related to B7-2/CD86.

Phosphorylation
Methylation
Ubiquitination
Cleavage
Glycosylation
Acetylation
Reduction
Ribosylation
Phosphorothioation
Biotinylation
Oxidation
Myristoylation
Demethylation
Carboxylation
Citrullination
Dephosphorylation
Prenylation
Acylation
Geranylgeranylation
Palmitoylation

Bioinformatics Tool for B7-2/CD86

Discover related pathways, diseases and genes to B7-2/CD86. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 

Related B7-2/CD86 Blog Posts

Check out the latest blog posts on B7-2/CD86.

CD86 - I work in tandem with CD80 CD86 belongs to the immunoglobulin superfamily of proteins that drive innate and adaptive immune responses. It is an 80kD co-stimulatory molecule for the priming and activation of naive and memory T-cells, respectively. CD86 is expressed on activated...    Read more.

Read more B7-2/CD86 related blogs.