B7-2/CD86 Products

Antibodies
B7-2/CD86 Antibody [Unconjuga ...
B7-2/CD86 Antibody [Unconjugated]
AF-141-NA
Species: Hu
Applications: WB, Flow, IHC, Neut
Host: Goat Polyclonal
Conjugate Catalog # Availability Size Price
Antibody Pairs
B7-2/CD86 Antibody Pair
B7-2/CD86 Antibody Pair
H00000942-PW1
Species: Hu
Applications: WB, IP
B7-2/CD86 Antibody Pair
B7-2/CD86 Antibody Pair
H00000942-AP41
Species: Hu
Applications: S-ELISA
B7-2/CD86 Antibody Pair
B7-2/CD86 Antibody Pair
H00000942-AP21
Species: Hu
Applications: S-ELISA
Lysates
B7-2/CD86 Overexpression Lysa ...
B7-2/CD86 Overexpression Lysate (D...
H00000942-T01
Species: Hu
Applications: WB
B7-2/CD86 Overexpression Lysa ...
B7-2/CD86 Overexpression Lysate (N...
NBP2-07567
Applications: WB
Proteins
B7-2/CD86 Recombinant Protein ...
B7-2/CD86 Recombinant Protein
H00000942-P01
Species: Hu
Applications: WB, ELISA, PA
B7-2/CD86 Partial Recombinant ...
B7-2/CD86 Partial Recombinant Protein
H00000942-Q01
Species: Hu
Applications: WB, ELISA, PA
B7-2/CD86 Recombinant Protein ...
B7-2/CD86 Recombinant Protein
H00000942-G01
Species: Hu
RNAi
B7-2/CD86 RNAi
B7-2/CD86 RNAi
H00000942-R03
Species: Hu
B7-2/CD86 RNAi
B7-2/CD86 RNAi
H00000942-R04
Species: Hu

Description

B7-2 (CD86) is an important costimulatory molecule for the priming and activation of naive and memory T cells, respectively. Soluble CD86 is produced by resting monocytes and results from an alternatively spliced transcript (CD86deltaTM) characterized by deletion of the transmembrane domain (1). Engagement of CD28 with B7-1 and B7-2 ligands on antigen-presenting cells (APCs) provides a stimulatory signal for T-cell activation, whereas subsequent engagement of CTLA-4 with these same ligands results in attenuation of the response. Given their central function in immune modulation, CTLA-4- and CD28-associated signaling pathways are primary therapeutic targets for preventing autoimmune disease, graft versus host disease, graft rejection and promoting tumor immunity (2). It has also been shown that on B cells and macrophages, heat shock proteins GroES and GroEL both stimulated the expression of B7-2 (3)

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Product By Gene ID 942
Alternate Names
  • B7-2
  • CD86 antigen
  • LAB72
  • T-lymphocyte activation antigen CD86
  • CTLA-4 counter-receptor B7.2
  • CD28 antigen ligand 2
  • FUN-1
  • B7-2 antigen
  • BU63
  • B-lymphocyte activation antigen B7-2
  • B70
  • Activation B7-2 antigen
  • CD28LG2B7-2 antigen)
  • MGC34413
  • CD86 molecule

Research Areas for B7-2/CD86

Find related products by research area and learn more about each of the different research areas below.

Adaptive Immunity
Cell Cycle and Replication
Dendritic Cell Markers
Diabetes Research
Immunology

Bioinformatics Tool for B7-2/CD86

Discover related pathways, diseases and genes to B7-2/CD86. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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Related B7-2/CD86 Blog Posts

Check out the latest blog posts on B7-2/CD86.
CD86 - I work in tandem with CD80
CD86 belongs to the immunoglobulin superfamily of proteins that drive innate and adaptive immune responses. It is an 80kD co-stimulatory molecule for the priming and activation of naive and memory T-cells, respectively. CD86 is expressed on activated...    Read more.
Read more B7-2/CD86 related blogs.