ATG16L1 Antibody

Product Discontinued

ATG16L1 Antibody Summary

• Immunogen: N-terminal of human ATG16-L1 protein conjugated to Blue Carrier Protein has been used as the immunogen.
• Specificity: IHC, WB and ELISA confirmed the specificity for ATG16 L1.
• Clonality: Polyclonal
• Host: Rabbit
• Gene: ATG16L1
• Purity: Unpurified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunocytochemistry/ Immunofluorescence 1:100-1:3000
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Western Blot 1:100-1:3000

Reactivity Notes

Human, rat. Other species not yet tested.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: Whole antisera
• Preservative: No Preservative
• Concentration: LYOPH
• Purity: Unpurified
• Reconstitution Instructions: Reconstitute with 0.1 ml of purified water.

Alternate Names for ATG16L1 Antibody

• APG16 autophagy 16-like (S. cerevisiae)
• APG16L beta
• APG16LFLJ10828
• APG16-like 1
• ATG16 autophagy related 16-like (S. cerevisiae)
• ATG16 autophagy related 16-like 1 (S. cerevisiae)
• ATG16A
• ATG16L
• autophagy-related protein 16-1
• FLJ00045
• FLJ10035
• FLJ22677
• IBD10
• WD repeat domain 30
• WDR30

Background

FUNCTION: Plays an essential role in autophagy. SUBUNIT: Homooligomer. Interacts with ATG5. Part of either the minor and major complexes respectively composed of 4 sets of ATG12-ATG5 and ATG16L1 (400 kDa) or 8 sets of ATG12-ATG5 and ATG16L1 (800 kDa). SUBCELLULAR LOCATION: Cytoplasm. Preautophagosomal structure; preautophagosomal structure membrane; peripheral membrane protein. Localized to preautophagosomal structure (PAS) where it is involved in the membrane targeting of ATG5. ALTERNATIVE PRODUCTS: 5 named isoforms produced by alternative splicing. SIMILARITY: Belongs to the WD repeat ATG16 family. SIMILARITY: Contains 7 WD repeats.



This product is distributed on behalf of Biosensis Pty. Ltd. of Australia.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for ATG16L1 Antibody (R-158-100)(2)

Publications using R-158-100

• Scharl M et al. Protein tyrosine phosphatase nonreceptor type 2 regulates autophagosome formation in human intestinal cells. 2011-01-01 [PMID: 21987459]
• Cooney R et al. NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation. Nat. Med. Dec 6 2009. 2009-01-01 [PMID: 19966812]

Bioinformatics

• Gene Symbol: ATG16L1
• Entrez:
  • 55054(Human)
  • 363278(Rat)
• Uniprot:
  • Q676U5(Human)