ARHGEF4 Antibody - BSA Free

Immunohistochemistry: ARHGEF4 Antibody - BSA Free [NBP3-47966] - Immunohistochemistry of paraffin-embedded human brain tissue slide using (ARHGEF4 Antibody) at dilution of 1:50

Western Blot: ARHGEF4 Antibody - BSA Free [NBP3-47966] - Mouse brain tissue were subjected to SDS PAGE followed by western blot with (ARHGEF4 Antibody) at dilution of 1:1000

• Reactivity: Hu, Mu
• Applications: WB, ELISA, IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free

ARHGEF4 Antibody - BSA Free Summary

• Immunogen: Rho guanine nucleotide exchange factor(GEF) 4. (Uniprot# Q9NR80)
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: ARHGEF4
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunohistochemistry 1:20-1:200
  • Western Blot 1:500-1:2000
• Theoretical MW: 72 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: PBS, 50% Glycerol, pH (7.3)
• Preservative: 0.02% Sodium Azide
• Purity: Immunogen affinity purified

Alternate Names for ARHGEF4 Antibody - BSA Free

• APC-stimulated guanine nucleotide exchange factor 1
• Asef
• ASEF1
• ASEFAPC-stimulated guanine nucleotide exchange factor
• GEF4
• KIAA1112
• Rho guanine nucleotide exchange factor (GEF) 4
• rho guanine nucleotide exchange factor 4
• STM6

Background

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through Gucleotide exchange protein coupled receptors. Acts as guanine nucleotide exchange factor (GEF) for RhoA and RAC1 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. This protein is similar to rat collybistin protein. Alternative splicing of the gene generates two transcript variants which encode different isoforms.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: ARHGEF4