ARAP1 Antibody (ARAP1-2) - BSA Free

Images

 
Immunocytochemistry/ Immunofluorescence: ARAP1 Antibody (ARAP1-2) [NB110-68801] - Colocalization of ARAP1 with DR4 at the plasma membrane and in early endosomes. ARAP1-transfected NCTC cells were treated with TRAIL for ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ICC/IF, IP
Clone
ARAP1-2
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Format
BSA Free
Concentration
1.0 mg/ml

ARAP1 Antibody (ARAP1-2) - BSA Free Summary

Immunogen
His6-tagged protein corresponding to amino acids 1190-1450 of human ARAP1
Specificity
The ARAP1-2 reacts with C-terminal part of ARAP1, a 160 kDa adaptor protein.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
ARAP1
Purity
Protein A purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunocytochemistry/Immunofluorescence 1:10-1:2000
  • Immunoprecipitation 1:50
  • Western Blot 2 ug/ml
Theoretical MW
160 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
PBS (pH 7.4)
Preservative
15mM Sodium Azide
Concentration
1.0 mg/ml
Purity
Protein A purified

Alternate Names for ARAP1 Antibody (ARAP1-2) - BSA Free

  • arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1
  • ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
  • centaurin, delta 2
  • Centaurin-delta-2
  • CENTD2ARF-GAP, RHO-GAP, ankyrin repeat, and pleckstrin homology domains-containingprotein 1
  • cnt-d2
  • KIAA0782centaurin-delta-2

Background

ARAP1 (angiotensin II type 1 receptor-associated protein) is an adaptor protein with ArfGAP and RhoGAP activities, containing five PH domains and ankyrin repeate. This adaptor seems to serve as a link between phosphoinositide- Arf-, and Rho-mediated cell signaling. ARAP1 supports the plasma membrane recycling of angiotensin II type 1 receptor (AT1) and is important also for cell-specific trafficking of pro-death receptor TRAIL-R1 (DR4) to the plasma membrane, thus promoting the TRAIL-induced apoptosis in certain cell types. ARAP1 also affects cell spreading.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol ARAP1
Entrez