MTUS1 Antibody (1C7)

Western Blot: MTUS1 Antibody (1C7) [H00057509-M01] - MTUS1 monoclonal antibody (M01), clone 1C7. Analysis of MTUS1 expression in human ovarian cancer.

Western Blot: MTUS1 Antibody (1C7) [H00057509-M01] - Western Blot analysis of MTUS1 expression in K-562 ( Cat # L009V1 ).

Sandwich ELISA: MTUS1 Antibody (1C7) [H00057509-M01] - Detection limit for recombinant GST tagged MTUS1 is approximately 0.3ng/ml as a capture antibody.

• Reactivity: Hu, Mu
• Applications: WB, ELISA, ICC/IF, IHC, IHC-P, S-ELISA
• Clone: 1C7
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated

MTUS1 Antibody (1C7) Summary

• Immunogen: MTUS1 (AAH33842, 1 a.a. ~ 240 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. MQLQEQFDNLNAAHETSKLEIEASHSEKLELLTKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMGKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWKLHNGDLCSPKRSPTSSAIPLQSPRNSGSFPSPSISPR
• Specificity: MTUS1 - mitochondrial tumor suppressor 1
• Isotype: IgG1 Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: MTUS1
• Purity: IgG purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunocytochemistry/Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Sandwich ELISA
  • Western Blot 1:500
• Application Notes: Antibody reactive against cell lysate and recombinant protein for western blot. It has also been used for ELISA.

Reactivity Notes

Human. Other species not tested.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: In 1x PBS, pH 7.4
• Preservative: No Preservative
• Purity: IgG purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for MTUS1 Antibody (1C7)

• Angiotensin-II type 2 receptor-interacting protein
• AT2 receptor-binding protein
• AT2R binding protein
• ATBPATIP1
• ATIP
• DKFZp586D1519
• erythroid differentiation-related
• FLJ14295
• GK1
• KIAA1288DKFZp686F20243
• microtubule associated tumor suppressor 1
• microtubule-associated tumor suppressor 1
• Mitochondrial tumor suppressor 1
• mitochondrial tumor suppressor gene 1
• MP44
• MTSG1AT2 receptor-interacting protein
• transcription factor MTSG1

Background

This gene encodes a protein which contains a C-terminal domain able to interact with the angiotension II (AT2) receptor and a large coiled-coil region allowing dimerization. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the transcript variants has been shown to encode a mitochondrial protein that acts as a tumor suppressor and partcipates in AT2 signaling pathways. Other variants may encode nuclear or transmembrane proteins but it has not been determined whether they also participate in AT2 signaling pathways.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for MTUS1 Antibody (H00057509-M01)(8)

Publications using H00057509-M01

• Rodrigues-Ferreira S, Nehlig A, Monchecourt C et al. Combinatorial expression of microtubule-associated EB1 and ATIP3 biomarkers improves breast cancer prognosis. Breast Cancer Res Treat. 2018-10-27 [PMID: 30368744]
• Zhao T, He Q, Liu Z et al. Angiotensin II type 2 receptor-interacting protein 3a suppresses proliferation, migration and invasion in tongue squamous cell carcinoma via the extracellular signal-regulated kinase-Snai2 pathway. Oncol Lett. 2015-11-10 [PMID: 26870214]
• Shinoda K, Luijten IH, Hasegawa Y et al. Genetic and functional characterization of clonally derived adult human brown adipocytes. Nat Med. 2015-03-16 [PMID: 25774848]
• Rogler Anja, Hoja Sabine, Giedl Johannes et al. Loss of MTUS1/ATIP expression is associated with adverse outcome in advanced bladder carcinomas: data from a retrospective study. BMC Cancer. 2014-03-20 [PMID: 24650297] (WB, Human)
• Guimond MO, Battista MC, Nikjouitavabi F et al. Expression and role of the angiotensin II AT2 receptor in human prostate tissue: In search of a new therapeutic option for prostate cancer. Prostate. 2013-02-06 [PMID: 23389987]
• Ding X, Zhang N, Cai Y et al. Down-regulation of tumor suppressor MTUS1/ATIP is associated with enhanced proliferation, poor differentiation and poor prognosis in oral tongue squamous cell carcinoma. Mol Oncol. 2011-11-18 [PMID: 22153618]
• Melcher R, Hartmann E, Zopf W et al. LOH and copy neutral LOH (cnLOH) act as alternative mechanism in sporadic colorectal cancers with chromosomal and microsatellite instability. Carcinogenesis. 2011-02-04 [PMID: 21297112]
• Rodrigues-Ferreira S, Di Tommaso A, Dimitrov A et al. 8p22 MTUS1 gene product ATIP3 is a novel anti-mitotic protein underexpressed in invasive breast carcinoma of poor prognosis. PLoS One 4(10):e7239. 2009-10-01 [PMID: 19794912]

Bioinformatics

• Gene Symbol: MTUS1
• Entrez:
  • 57509(Human)
• Uniprot:
  • AAH33842(Human)