APPL Antibody

Product Discontinued

APPL Antibody Summary

• Immunogen: APPL (NP_036228, 611 a.a. ~ 709 a.a) partial recombinant protein with GST tag.EGEKICDSVGLAKQIALHAELDRRASEKQKEIERVKEKQQKELNKQKQIEKDLEEQSRLIAASSRPNQASSEGQFVVLSSSQSEESDLGEGGKKRESE
• Specificity: APPL - adaptor protein containing pH domain, PTB domain and leucine zipper motif 1
• Isotype: IgG
• Clonality: Polyclonal
• Host: Mouse
• Gene: APPL1
• Purity: Unpurified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Western Blot 1:500
• Application Notes: Antibody reactive against cell lysate and recombinant protein for western blot. It has also been used for ELISA.

Reactivity Notes

Human, Mouse.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: 50% Glycerol
• Preservative: No Preservative
• Purity: Unpurified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for APPL Antibody

• Adapter protein containing PH domain, PTB domain and leucine zipper motif 1
• adaptor protein containing pH domain, PTB domain and leucine zipper motif 1
• adaptor protein, phosphotyrosine interaction, PH domain and leucine zippercontaining 1
• AKT2 interactor
• APPL
• APPL1
• APPLdip13-alpha
• DCC-interacting protein 13-alpha
• DIP 13 alpha
• DIP13A
• DIP13alpha
• Dip13-alpha
• KIAA1428
• signaling adaptor protein DIP13alpha

Background

The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for APPL Antibody (H00026060-A01)(1)

Publication using H00026060-A01

• Blandin G, Marchand S, Charton K et al. A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome. Skelet Muscle 2013-02-15 [PMID: 23414517] (WB, Human)

Bioinformatics

• Gene Symbol: APPL1
• Entrez:
  • 26060(Human)
• OMIM:
  • 604299(Human)
• Uniprot:
  • NP_036228(Human)