Apolipoprotein H/ApoH Antibody (517038) [Alexa Fluor® 405]

• Reactivity: Hu
• Applications: WB
• Clone: 517038
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 405

Apolipoprotein H/ApoH Antibody (517038) [Alexa Fluor® 405] Summary

• Immunogen: E. coli-derived recombinant human Apolipoprotein H/ApoH
  Gly20-Cys345
  Accession # P02749
• Specificity: Detects endogenous human Apolipoprotein H/ApoH in Western blots.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Apolipoprotein H/ApoH Antibody (517038) [Alexa Fluor® 405]

• Activated protein C-binding protein
• Anticardiolipin cofactor
• APC inhibitor
• APOH
• apo-H
• apolipoprotein H (beta-2-glycoprotein I)
• Apolipoprotein H
• B2G1
• B2GP1
• B2GPI
• Beta
• beta(2)GPI
• beta-2-glycoprotein 1
• Beta-2-glycoprotein I
• BG

Background

Apolipoprotein H (ApoH also known as beta 2-Glycoprotein 1/ beta 2-GPI) is a 50 kDa secreted monomeric glycoprotein member of the complement control superfamily of molecules. It is produced by hepatocytes and is bound to HDL particles. Circulating ApoH blocks the intrinsic clotting pathway and binds to exposed phospholipids on apoptotic cells. Mature human ApoH contains four Sushi repeats (aa 21‑260) and one C-terminal kringle domain (aa 261‑345) that binds heparin and phospholipids. At least two isoforms exist. One shows a 31 aa substitution for aa 140‑345, while a second represents a bioactive plasmin cleavage product that removes the C-terminal nine amino acids. Mature human ApoH shares 76% aa identity with mouse ApoH.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.