Apolipoprotein A5 Antibody (4H8H8E2)

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Immunocytochemistry/ Immunofluorescence: Apolipoprotein A5 Antibody (4H8H8E2) [NB110-57307] - Apolipoprotein A5 antibody (1:250) was tested in HepG2 cells with Dylight 488 (green). Nuclei and alpha-tubulin were ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA, Flow, ICC/IF
Clone
4H8H8E2
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
1.2 mg/ml

Apolipoprotein A5 Antibody (4H8H8E2) Summary

Immunogen
Ni-NTA purified full-length recombinant human Apolipoprotein A5 expressed in E. Coli strain BL21 (DE3). [UniProt# Q6Q788]
Localization
Secreted
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
APOA5
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • ELISA 1:100-1:2000
  • Flow Cytometry
  • Immunocytochemistry/Immunofluorescence 1:250
Positive Control
Apolipoprotein A5 Lysate (NBL1-07611)
Publications
Read Publication using NB110-57307.

Reactivity Notes

Human.

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.1% Sodium Azide
Concentration
1.2 mg/ml
Purity
Protein G purified

Alternate Names for Apolipoprotein A5 Antibody (4H8H8E2)

  • APOAV
  • apo-AV
  • APOA-V
  • Apolipoprotein A5
  • apolipoprotein A-V
  • FLJ97995
  • MGC126836
  • RAP3MGC126838
  • Regeneration-associated protein 3

Background

Apolipoprotein A-V (APOA5) belongs to apolipoprotein A1/A4/E family and is a component of several lipoprotein fractions, including VLDL, HDL and chylomicrons. Expressed at high levels in plasma and liver, APOA5 exists as a secreted protein and interacts with GPIHBP1. APOA5 is an important determinant of plasma triglyceride levels by both behaving as a potent stimulator of apo-CII lipoprotein lipase/LPL TG hydrolysis and an inhibitor of hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate). APOA5 activates lecithin: cholesterol acyltransferase (LCAT) but does not enhance efflux of cholesterol from macrophages. Transgenic mice overexpressing human APOA5 gene exhibit one-third lower plasma TG levels than wild type, whereas APOA5 knockout mice possess four times as much plasma TG levels, with no effect on plasma cholesterol levels. Clinically, defects in APOA5 are a cause of susceptibility to familial hypertriglyceridemia (FHTR) and hyperlipoproteinemia type 5 (HLPP5).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Apolipoprotein A5 Antibody (NB110-57307)(1)

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Product General Protocols

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Video Protocols

ICC/IF Video Protocol

FAQs for Apolipoprotein A5 Antibody (NB110-57307) (0)

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Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 405 Labeled NB110-57307AF405
Alexa Fluor 488 Labeled NB110-57307AF488
Alexa Fluor 647 Labeled NB110-57307AF647
Alexa Fluor 700 Labeled NB110-57307AF700
Biotin Labeled NB110-57307B
DyLight 405 Labeled NB110-57307V
DyLight 488 Labeled NB110-57307G
DyLight 550 Labeled NB110-57307R
DyLight 650 Labeled NB110-57307C
FITC Labeled NB110-57307F
HRP Labeled NB110-57307H

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Bioinformatics

Gene Symbol APOA5