Apc2 Antibody (3A2G2)

Images

 
Western Blot: Apc2 Antibody (3A2G2) [NBP2-61656] - Analysis using APC2 mAb against human APC2 (AA: 2041-2181) recombinant protein. (Expected MW is 40.9 kDa)
Immunocytochemistry/ Immunofluorescence: Apc2 Antibody (3A2G2) [NBP2-61656] - Analysis of Hela cells using APC2 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa ...read more
Immunohistochemistry: Apc2 Antibody (3A2G2) [NBP2-61656] - Analysis of paraffin-embedded bladder cancer tissues using APC2 mouse mAb with DAB staining.
Flow Cytometry: Apc2 Antibody (3A2G2) [NBP2-61656] - Analysis of Hela cells using APC2 mouse mAb (green) and negative control (red).
Western Blot: Apc2 Antibody (3A2G2) [NBP2-61656] - Analysis using APC2 mAb against HEK293 (1) and APC2 (AA: 2041-2181)-hIgGFc transfected HEK293 (2) cell lysate.
Immunohistochemistry: Apc2 Antibody (3A2G2) [NBP2-61656] - Analysis of paraffin-embedded ovarian cancer tissues using APC2 mouse mAb with DAB staining.
ELISA: Apc2 Antibody (3A2G2) [NBP2-61656] - Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)

Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, ELISA, Flow, ICC/IF, IHC
Clone
3A2G2
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

Apc2 Antibody (3A2G2) Summary

Immunogen
Purified recombinant fragment of human APC2 (AA: 2041-2181) expressed in E. Coli.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
APC2
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • ELISA 1:100-1:2000
  • Flow Cytometry 1:10-1:1000
  • Immunocytochemistry/Immunofluorescence 1:10-1:500
  • Immunohistochemistry 1:10-1:1000
Theoretical MW
244 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Protein G purified

Alternate Names for Apc2 Antibody (3A2G2)

  • adenomatosis polyposis coli 2
  • adenomatous polyposis coli like
  • adenomatous polyposis coli protein 2
  • APCL

Background

This gene encodes a strongly conserved protein that has an N-terminal coiled-coil domain followed by an armadillo domain, five 20-amino acid repeats, and two SAMP domains. This protein promotes the assembly of a multiprotein complex that recruits and phosphorylates the Wnt effector beta-catenin and targets beta-catenin for ubiquitylation and proteasomal degradation. This protein therefore plays a role in the reduction of cytoplasmic levels of beta-catenin which in turn reduces activation of Wnt target genes that play a pivotal role in the pathogenesis of various human cancers. The protein encoded by this gene is closely related to the adenomatous polyposis coli (APC) tumor-suppressor protein and has similar tumor-suppressor effects. This gene also plays a role in actin assembly, cell-cell adhesion, and microtubule network formation through its interaction with cytoskeletal proteins. This gene has its highest expression in the central nervous system and is involved in brain development through cytoskeletal regulation in neurons. Alternative splicing produces multiple transcript variants encoding distinct isoforms.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

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Array NBP2-61656

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Bioinformatics

Gene Symbol APC2