Apc2 Products

Description

APC2, also known as Anaphase promoting complex subunit 2, APC2, Cyclosome subunit 2, and ANAPC2, is a component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/cyclosome protein complex promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitors, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains at least eleven subunits. The composition of APC is highly conserved in organisms from yeast to humans. APC2 is a cullin family member that interacts through the cullin domain with ANAPC11 and UBCH10.

Bioinformatics

Entrez	10297 Human
Product By Gene ID	10297
Alternate Names	adenomatosis polyposis coli 2 adenomatous polyposis coli like adenomatous polyposis coli protein 2 APCL

Research Areas for Apc2

Find related products by research area and learn more about each of the different research areas below.

Cell Biology
Cell Cycle and Replication
Ubiquitin Proteasome Pathway