Angiotensin I Antibody (BGN/KA/4H)

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA
Clone
BGN/KA/4H
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Angiotensin I Antibody (BGN/KA/4H) Summary

Immunogen
Synthetic peptide corresponding to amino acids 40-49 of the angiotensinogen precursor (Swiss-Prot entry P01019) conjugated to HMW carrier protein.
Epitope
P-F-H-L-V-I-H-N-E-S(-C)
Specificity
NB100-62344 is specific for Angiotensin I and does not react with angiotensin II, III or angiotensinogen in ELISA. Enzyme (ACE) into a vasoactive form called Angiotensin II which is responsible for increasing blood pressure. Angiotensin I is important in the Renin-Angiotensin-Aldosterone System (RAAS). RAAS is responsible for the regulation of blood pressure and water retention in the body. Angiotensin I is produced from a reaction between the renal enzyme Renin and angiotensinogen. It is converted by Angiotensin Converting Enzyme (ACE) into a vasoactive form called Angiotensin II which is responsible for increasing blood pressure.
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Gene
AGT
Purity
Protein A purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • ELISA 1:12000-1:100000
Positive Control
Serpin A8/Angiotensinogen Lysate (NBL1-07391)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.09% Sodium Azide
Concentration
1.0 mg/ml
Purity
Protein A purified

Alternate Names for Angiotensin I Antibody (BGN/KA/4H)

  • alpha-1 antiproteinase, antitrypsin
  • angiotensin II
  • angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
  • angiotensinogen
  • ANHU
  • FLJ92595
  • FLJ97926
  • pre-angiotensinogen
  • serine (or cysteine) proteinase inhibitor
  • Serpin A8
  • SERPINA8angiotensin I

Background

The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

Additional Angiotensin I Products

Angiotensin I NB100-62344

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Bioinformatics

Gene Symbol AGT
Entrez
Uniprot