Amphiphysin/AMPH Antibody (694145) [CoraFluor™ 1]

• Reactivity: Hu
• Applications: IHC
• Clone: 694145
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: CoraFluor 1

Amphiphysin/AMPH Antibody (694145) [CoraFluor™ 1] Summary

• Immunogen: E. coli-derived recombinant human Amphiphysin/AMPH
  Asn204-Gly300
  Accession # P49418
• Specificity: Detects human Amphiphysin/AMPH in direct ELISAs.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Gene: AMPH
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark. Do not freeze.
• Buffer: PBS
• Preservative: No Preservative
• Purity: Protein A or G purified from hybridoma culture supernatant

Notes

CoraFluor (TM) is a trademark of Bio-Techne Corp. Sold for research purposes only under agreement from Massachusetts General Hospital. US patent 2022/0025254

Alternate Names for Amphiphysin/AMPH Antibody (694145) [CoraFluor™ 1]

• AMPH
• AMPH1
• amphiphysin (Stiff-Man syndrome with breast cancer 128kDa autoantigen)
• amphiphysin (Stiff-Mann syndrome with breast cancer 128kD autoantigen)
• amphiphysin I
• Amphiphysin

Background

Amphiphysin, a neuronal protein first identified in chicken synaptic membranes, is the autoantigen of Stiff-Man Syndrome (SMS) associated with breast cancer. Patient autoantibodies have a distinct pattern of reactivity with amphiphysin, and the dominant autoepitope is located in its C-terminal region, which contains an SH3 domain (1). Amphiphysin is expressed in many neurons, certain endocrine cell types, and spermatocytes (2). study suggests a link between amphiphysin I expression in cancer and amphiphysin I autoimmunity. The enhanced expression of amphiphysin I in some forms of cancer supports the hypothesis that amphiphysin family members may play a role in the biology of cancer cells (3).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: AMPH