Amphiphysin/AMPH Products

Description

Amphiphysin, a neuronal protein first identified in chicken synaptic membranes, is the autoantigen of Stiff-Man Syndrome (SMS) associated with breast cancer. Patient autoantibodies have a distinct pattern of reactivity with amphiphysin, and the dominant autoepitope is located in its C-terminal region, which contains an SH3 domain (1). Amphiphysin is expressed in many neurons, certain endocrine cell types, and spermatocytes (2). study suggests a link between amphiphysin I expression in cancer and amphiphysin I autoimmunity. The enhanced expression of amphiphysin I in some forms of cancer supports the hypothesis that amphiphysin family members may play a role in the biology of cancer cells (3).

Bioinformatics

Entrez	218038 Mouse 273 Human 60668 Rat
Uniprot	AAH34376 Human AAH34376.1 Human NM_001635 Human NP_001626.1 Human P49418 Human
Product By Gene ID	273
Alternate Names	AMPH1 amphiphysin (Stiff-Man syndrome with breast cancer 128kDa autoantigen) amphiphysin (Stiff-Mann syndrome with breast cancer 128kD autoantigen) amphiphysin I amphiphysin

Research Areas for Amphiphysin/AMPH

Find related products by research area and learn more about each of the different research areas below.

Cancer
Immune System Diseases
Immunology
Tumor Suppressors