alpha-2B Adrenergic R/ADRA2B Antibody [CoraFluor™ 1]

• Reactivity: Hu
• Applications: WB, IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: CoraFluor 1

alpha-2B Adrenergic R/ADRA2B Antibody [CoraFluor™ 1] Summary

• Description: CoraFluor(TM) 1 is a high performance terbium-based TR-FRET (Time-Resolved Fluorescence Resonance Energy Transfer) or TRF (Time-Resolved Fluorescence) donor for high throughput assay development. CoraFluor(IM) 1 absorbs UV light at approximately 340 nm, and emits at approximately 490 nm, 545 nm, 585 nm and 620 nm. It is compatible with common acceptor dyes that absorb at the emission wavelengths of CoraFluor(TM) 1. CoraFluor(TM) 1 can be used for the development of robust and scalable TR-FRET binding assays such as target engagement, ternary complex, protein-protein interaction and protein quantification assays.
• Immunogen: Produced in rabbits immunized with E. coli-derived Human alpha-2B Adrenergic R/ADRA2B fragment.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: ADRA2B
• Purity: Antigen and protein A Affinity-purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark. Do not freeze.
• Buffer: PBS
• Preservative: No Preservative
• Purity: Antigen and protein A Affinity-purified

Notes

CoraFluor (TM) is a trademark of Bio-Techne Corp. Sold for research purposes only under agreement from Massachusetts General Hospital. US patent 2022/0025254

Alternate Names for alpha-2B Adrenergic R/ADRA2B Antibody [CoraFluor™ 1]

• a-2B AdrenergicR
• ADRA2B adrenergic, alpha-2B-, receptor
• ADRA2B
• ADRA2L1
• ADRA2L1adrenergic receptor alpha 2B
• ADRA2RL1
• ADRARL1
• adrenergic, alpha-2B-, receptor
• Alpha-2 adrenergic receptor subtype C2
• alpha-2-adrenergic receptor-like 1
• alpha-2B Adrenergic R
• alpha-2B adrenergic receptor
• alpha2B AdrenergicR
• Alpha-2B adrenoceptor
• Alpha-2B adrenoreceptor
• alpha-2B-adrenergic receptor
• ALPHA2BAR
• alpha-2BAR
• G-protein coupled receptor

Background

Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. This gene encodes the alpha2B subtype, which was observed to associate with eIF-2B, a guanine nucleotide exchange protein that functions in regulation of translation. A polymorphic variant of the alpha2B subtype, which lacks 3 glutamic acids from a glutamic acid repeat element, was identified to have decreased G protein-coupled receptor kinase-mediated phosphorylation and desensitization; this polymorphic form is also associated with reduced basal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of obesity. This gene contains no introns in either its coding or untranslated sequences. (provided by RefSeq)

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: ADRA2B