alpha-2B Adrenergic R/ADRA2B Antibody [Alexa Fluor® 405]

• Reactivity: Hu
• Applications: WB, IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Alexa Fluor 405

alpha-2B Adrenergic R/ADRA2B Antibody [Alexa Fluor® 405] Summary

• Immunogen: Produced in rabbits immunized with E. coli-derived Human alpha-2B Adrenergic R/ADRA2B fragment.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: ADRA2B
• Purity: Antigen and protein A Affinity-purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Antigen and protein A Affinity-purified

Notes

Alexa Fluor (R) products are provided under an intellectual property license from Life Technologies Corporation. The purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: (i) in manufacturing; (ii) to provide a service, information, or data in return for payment; (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5791 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@lifetech.com. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for alpha-2B Adrenergic R/ADRA2B Antibody [Alexa Fluor® 405]

• a-2B AdrenergicR
• ADRA2B adrenergic, alpha-2B-, receptor
• ADRA2B
• ADRA2L1
• ADRA2L1adrenergic receptor alpha 2B
• ADRA2RL1
• ADRARL1
• adrenergic, alpha-2B-, receptor
• Alpha-2 adrenergic receptor subtype C2
• alpha-2-adrenergic receptor-like 1
• alpha-2B Adrenergic R
• alpha-2B adrenergic receptor
• alpha2B AdrenergicR
• Alpha-2B adrenoceptor
• Alpha-2B adrenoreceptor
• alpha-2B-adrenergic receptor
• ALPHA2BAR
• alpha-2BAR
• G-protein coupled receptor

Background

Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. This gene encodes the alpha2B subtype, which was observed to associate with eIF-2B, a guanine nucleotide exchange protein that functions in regulation of translation. A polymorphic variant of the alpha2B subtype, which lacks 3 glutamic acids from a glutamic acid repeat element, was identified to have decreased G protein-coupled receptor kinase-mediated phosphorylation and desensitization; this polymorphic form is also associated with reduced basal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of obesity. This gene contains no introns in either its coding or untranslated sequences. (provided by RefSeq)

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: ADRA2B