alpha-2B Adrenergic R/ADRA2B Products

Description

Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. This gene encodes the alpha2B subtype, which was observed to associate with eIF-2B, a guanine nucleotide exchange protein that functions in regulation of translation. A polymorphic variant of the alpha2B subtype, which lacks 3 glutamic acids from a glutamic acid repeat element, was identified to have decreased G protein-coupled receptor kinase-mediated phosphorylation and desensitization; this polymorphic form is also associated with reduced basal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of obesity. This gene contains no introns in either its coding or untranslated sequences. (provided by RefSeq)

Bioinformatics

Entrez	151 Human
Uniprot	P18089 Human
Product By Gene ID	151
Alternate Names	ADRA2B adrenergic, alpha-2B-, receptor ADRA2L1adrenergic receptor alpha 2B ADRA2RL1 ADRARL1 adrenergic, alpha-2B-, receptor Alpha-2 adrenergic receptor subtype C2 alpha-2-adrenergic receptor-like 1 alpha-2B adrenergic receptor Alpha-2B adrenoceptor Alpha-2B adrenoreceptor alpha-2B-adrenergic receptor ALPHA2BAR Alpha-2BAR alpha-2BAR G-protein coupled receptor

Research Areas for alpha-2B Adrenergic R/ADRA2B

Find related products by research area and learn more about each of the different research areas below.

Adaptive Immunity
Immunology
Innate Immunity