Aldo-keto Reductase 1C3/AKR1C3 Antibody

Western Blot: Aldo-keto Reductase 1C3/AKR1C3 Antibody [H00008644-D01P] - Analysis of AKR1C3 expression in human colon.

Western Blot: Aldo-keto Reductase 1C3/AKR1C3 Antibody [H00008644-D01P] - Analysis of AKR1C3 expression in transfected 293T cell line by AKR1C3 polyclonal antibody.Lane 1: AKR1C3 transfected lysate(36.90 KDa).Lane 2: Non-transfected lysate.

Product Discontinued

Aldo-keto Reductase 1C3/AKR1C3 Antibody Summary

• Immunogen: AKR1C3 (NP_003730.4, 1 a.a. - 323 a.a.) full-length human protein. MDSKHQCVKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPMSLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLDRNLHYFNSDSFASHPNYPYSDEY
• Specificity: Reacts with aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II).
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: AKR1C3
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: This antibody is reactive against tissue and transfected lysate in WB and as a detection antibody in ELISA.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.4)
• Preservative: No Preservative
• Purity: Protein A purified

Notes

Quality control test: Antibody reactive against mammalian transfected lysate.

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for Aldo-keto Reductase 1C3/AKR1C3 Antibody

• 17-beta-hydroxysteroid dehydrogenase type 5
• 3-alpha-HSD type 2
• 3-alpha-hydroxysteroid dehydrogenase type 2
• AKR1C3
• Aldo-keto Reductase 1C3
• aldo-keto reductase family 1 member C3
• aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
• AldoketoReductase 1C3
• Chlordecone reductase homolog HAKRb
• DD3
• DD-3
• DD317-beta-HSD 5
• DDH1
• DDX
• Dihydrodiol dehydrogenase 3
• Dihydrodiol dehydrogenase type I
• dihydrodiol dehydrogenase X
• EC 1.1.1
• EC 1.1.1.112,3-alpha-HSD type II, brain
• EC 1.1.1.188
• EC 1.1.1.213
• EC 1.1.1.63
• EC 1.1.1.64
• EC 1.3.1.20
• HA1753
• HAKRB
• HAKRBtype IIb 3-alpha hydroxysteroid dehydrogenase
• HAKRe
• HSD17B5
• hydroxysteroid (17-beta) dehydrogenase 5
• Indanol dehydrogenase
• KIAA0119hluPGFS
• PGFS
• Prostaglandin F synthase
• Testosterone 17-beta-dehydrogenase 5
• Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase

Background

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Aldo-keto Reductase 1C3/AKR1C3 Antibody (H00008644-D01P)(2)

Publications using H00008644-D01P

• Park SH, Kim JH, Ko E et al. Resistance to gefitinib and cross-resistance to irreversible EGFR-TKIs mediated by disruption of the Keap1-Nrf2 pathway in human lung cancer cells. FASEB J May 29 2018 [PMID: 29812969]
• Quinones-Lombrana A, Ferguson D, Hageman Blair R et al. Interindividual Variability in the Cardiac Expression of Anthracycline Reductases in Donors With and Without Down Syndrome. Pharm Res. 2014 Feb 22 [PMID: 24562808]

Bioinformatics

• Gene Symbol: AKR1C3
• Entrez:
  • 8644(Human)
• Uniprot:
  • NP_003730.4(Human)