Aggrecan Antibody (726006) [PerCP]

• Reactivity: Hu
• Applications: WB
• Clone: 726006
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: PerCP

Aggrecan Antibody (726006) [PerCP] Summary

• Immunogen: Aggrecan cleaved C-term aa 393-402
  ARGSVILTVK
  Accession # P16112
• Specificity: Detects human Aggrecan in direct ELISAs and Western blots. It specifically recognizes the C-terminal fragment of recombinant human Aggrecan released following cleavage by ADAMTS5.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Gene: ACAN
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from hybridoma culture supernatant

Alternate Names for Aggrecan Antibody (726006) [PerCP]

• ACAN
• AGC1
• AGC1SEDK
• aggrecan core protein
• Aggrecan
• Cartilage-specific proteoglycan core protein
• Chondroitin sulfate proteoglycan 1
• Chondroitin sulfate proteoglycan core protein 1
• CSPCP
• CSPG1
• CSPG1aggrecan 1
• CSPGCP
• large aggregating proteoglycan
• MSK16
• MSK16AGCAN
• SEDK

Background

This aggrecan degradation product usually remains within the tissue still complexed to hyaluronan and link protein. Its release from the cartilage usually signals that there has been extensive catabolism of aggrecan, which allows large complexes containing this metabolite to be released from the tissue.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: ACAN