Activin RIIB Antibody (60408) [Alexa Fluor™ Plus 555]

• Reactivity: Hu
• Clone: 60408
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 555

Activin RIIB Antibody (60408) [Alexa Fluor™ Plus 555] Summary

• Specificity: Detects human Activin RIIB in direct ELISAs and Western blots. Shows approximately 5% cross‑reactivity with recombinant human Activin RIIA.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Activin RIIB Antibody (60408) [Alexa Fluor™ Plus 555]

• activin A receptor, type IIB
• Activin receptor type IIB
• activin receptor type-2B
• Activin RIIB
• ActivinRIIB
• ACTRIIB
• ActR-IIB
• ACVR2B
• EC 2.7.11
• EC 2.7.11.30
• MGC116908

Background

Members of the TGF-beta superfamily exert their biological effects by binding to heteromeric complexes of a type I and a type II serine-threonine kinase receptor, both of which are essential for signal transduction. Activin receptor type IIB is a type II receptor that mediates multiple signals for transforming growth factor-beta (TGF-beta ) family members, including Activin, Nodal, BMP-7, GDF-1, GDF-3, Myostatin (GDF-8), and GDF-11. Through alternative mRNA splicing, multiple ActR-IIB isoforms can also be generated.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.