ACK1 Antibody

Product Discontinued

ACK1 Antibody Summary

• Immunogen: TNK2 (AAH08884, 21 a.a. ~ 120 a.a) partial recombinant protein with GST tag.QYFLRLRDDLNVTRLSHFEYVKNEDLEKIGMGRPGQRRLWEAVKRRKALCKRKSWMSKVFSGKRLEAEFPPHHSQSTFRKTSPAPGGPAGEGPLQSLTCL
• Specificity: TNK2 - tyrosine kinase, non-receptor, 2
• Isotype: IgG
• Clonality: Polyclonal
• Host: Mouse
• Gene: TNK2
• Purity: Unpurified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Western Blot 1:500
• Application Notes: Antibody reactive against cell lysate and recombinant protein for western blot. It has also been used for ELISA.

Reactivity Notes

Human. Other species not tested.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: Whole antisera with 50% Glycerol
• Preservative: No Preservative
• Purity: Unpurified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for ACK1 Antibody

• ACK1
• ACK-1
• ACK1ACKp21cdc42Hs
• activated CDC42 kinase 1
• activated Cdc42-associated kinase 1
• activated p21cdc42Hs kinase
• EC 2.7.10
• EC 2.7.10.2
• FLJ44758
• FLJ45547
• TNK2
• Tyrosine kinase non-receptor protein 2
• tyrosine kinase, non-receptor, 2

Background

This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for ACK1 Antibody (H00010188-A01)(1)

Publication using H00010188-A01

• Thaker Youg R, Recino Asha, Raab Monika et al. Activated Cdc42-associated kinase 1 (ACK1) binds the sterile a motif (SAM) domain of the adaptor SLP-76 and phosphorylates proximal tyrosines. J Biol Chem 2017-01-01 [PMID: 28188290] (WB, Human)

Bioinformatics

• Gene Symbol: TNK2
• Entrez:
  • 10188(Human)
• OMIM:
  • 606994(Human)
• Uniprot:
  • AAH08884(Human)