Abeta 40 Antibody

Product Discontinued

Abeta 40 Antibody Summary

• Immunogen: Synthetic peptide, corresponding to amino acids 1-40 of Human beta Amyloid.
• Localization: Plasma membrane
• Specificity: beta Amyloid 1-40
• Clonality: Polyclonal
• Host: Rabbit
• Gene: APP
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunohistochemistry
  • Radioimmunoassay
• Application Notes: ELISA: Use at an assay dependent dilution. RIA: Use at an assay dependent dilution. Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user.

Reactivity Notes

Cross-reacts with Human.Not yet tested in other species.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: Dulbecco's PBS (pH 7.3)
• Preservative: No Preservative
• Concentration: 0.24 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for Abeta 40 Antibody

• amyloid beta 40
• Beta-amyloid protein 40

Background

Amyloid beta-protein (Abeta) is associated with neuronal injury and death in Alzheimer's disease. The most common isoforms are of Amyloid beta are Abeta40 and Abeta42.

The Amyloid beta A4 protein (Abeta40) is the more common isoform and is the main components of amyloid plaques. Abeta-40 is produced by cleavage of the Amyloid Precursor Protein (APP) that occurs in the endoplasmic reticulum.

The Amyloid beta proteins function as a cell surface receptor and supports neurite growth, neuronal adhesion and axonogenesis on the surface of neurons. Amyloid betas are also involved in cell mobility functions and transcription regulation via various protein-protein interactions.

Abeta40 antibodies are useful tools for Alzheimer's studies and research on amyloid plaques.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: APP
• Entrez:
  • 351(Human)