Amyloid beta and Methionine Sulfoxide Related to Abeta 42 Antibody and Abeta 40 Antibody

Thu, 10/27/2011 - 12:03

By Eric Neeley

Alzheimer's disease is a devastating neurodegenerative illness characterized by the formation of plaques, tangles, and eventually synaptic loss. Amyloid beta (Aβ) is the processed form of the Amyloid precursor protein (APP), and whose aggregation eventually forms the amyloid plaques of the disease. APP is cleaved by alpha, beta, and gamma secretases to form numerous peptide isoforms of various lengths, but most common are 40 and 42, which are created by the later of the secretases. Both forms of the peptide are important for research, as is the need for tools that can differentiate between the two. Although Aβ40 is more common, Aβ42 is thought to be more toxic of the two because of its greater ability to form aggregates.

Immunocytochemistry/Immunofluorescence: beta Amyloid Antibody

The Abeta peptides are also known to produce free radicals that lead to neurotoxicity. Interestingly, the methionine at position 35 (Met-35) may facilitate this toxicity. Met-35 has the ability to become oxidized to form methionine sulfoxide, which can decrease the biological activity of the peptide. These oxidized peptides constitute a large portion of the of the Abeta population from Alzheimer’s brains. Conversion to the non-oxidized state is mediated by methionine sulfoxide reductase, whose presence is also decreased in the disease compared to control brains.

Novus Biologicals offers Amyloid beta reagents for your research needs including:



Great put up, very informative. I'm wondering why the other experts of this sector don't understand this. You should continue your writing. I'm sure, you have a huge readers' base already!|What's Taking place i am new to this, I stumbled upon this I have discovered It positively useful and it has aided me out loads. I'm hoping to give a contribution & aid other users like its helped me. Good job.

Blog Topics