ABCG2/CD338 Antibody (MM0047-2J39) - Azide and BSA Free

Immunohistochemistry-Paraffin: ABCG2/CD338 Antibody (MM0047-2J39) [NB110-93511] - Normal Human Placenta Tissue

Product Discontinued

ABCG2/CD338 Antibody (MM0047-2J39) - Azide and BSA Free Summary

• Immunogen: Human recombinant ABCG2/CD338
• Marker: Stem Cell Marker
• Isotype: IgG2
• Clonality: Monoclonal
• Host: Mouse
• Gene: ABCG2
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • CyTOF-ready
  • Flow Cytometry 1:100-1:1000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:100-1:1000
• Application Notes: This antibody is Cytof ready.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: Lyophilized from a 0.2 um filtered solution in PBS. 0.025 mg size is provided in liquid form, PBS
• Preservative: No Preservative
• Concentration: LYOPH
• Purity: Protein G purified
• Reconstitution Instructions: Reconstitute with sterilized PBS to a final concentration of 0.2 mg/ml.

Alternate Names for ABCG2/CD338 Antibody (MM0047-2J39) - Azide and BSA Free

• ABC transporter
• ABC15
• ABCG2
• ABCP
• ABCPMGC102821
• ATP-binding cassette sub-family G member 2
• ATP-binding cassette transporter G2
• ATP-binding cassette, sub-family G (WHITE), member 2
• BCRP
• BCRP1
• BCRPMRX
• BMDP
• Breast cancer resistance protein
• CD338 antigen
• CD338
• CDw338
• EST157481
• mitoxantrone resistance protein
• Mitoxantrone resistance-associated protein
• MXR
• MXRMXR1
• placenta specific MDR protein
• Placenta-specific ATP-binding cassette transporter

Background

An ABC transporter. Allows efflux of Hoechst dye, a property that has been used to separate bone marrow side population cells, which express BCRP/ABCG2. Appears to play a major role in the multidrug resistance phenotype of a specific MCF-7 breast cancer cell line. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase in the efflux of rhodamine 123.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for ABCG2/CD338 Antibody (NB110-93511)(1)

Publication using NB110-93511

• Marzagalli M, Moretti RM, Messi E et al. Targeting melanoma stem cells with the Vitamin E derivative delta-tocotrienol Sci Rep 2018-01-12 [PMID: 29330434] (FLOW, Human)

Bioinformatics

• Gene Symbol: ABCG2
• Entrez:
  • 9429(Human)