ABCG2/CD338 Products

Description

Tumor cells may display a multidrug resistant phenotype by overexpression of ATP-binding cassette transporters such as multidrug resistance (MDRI) p-glycoprotein, multidrug resistance protein 1 (MRP1), and breast cancer resistance protein (BCRP). Tumor cells can be intrinsically resistant to drugs or they can acquire resistance to structurally and functionally unrelated drugs on drug exposure. This phenomenon is known as multidrug resistance (MDR). In human tumor cells, several transporter proteins can be involved in MDR. These proteins, MDR1 P-gp (ABCB1), MRP1 (ABCC1), MRP2 (ABCC2), MRP3 (ABCC3), and BCRP (ABCG2), belong to the ABC transporter family. They act as efflux pumps, which result in decreased intracellular concentrations of cytotoxic drugs. BCRP is a recently discovered half-transporter that probably acts as a homo- or heterodimer in transporting cytotoxic agents. The transporter molecule is capable of transporting several anticancer drugs but has thus far been found mainly in MX-resistant cell lines.

Bioinformatics

Entrez	26357 Mouse 9429 Human
Uniprot	AAH21281.1 Human NM_004827 Human NP_004818 Human NP_004818.2 Human Q7TMS5 Mouse Q9UNQ0 Human
Product By Gene ID	9429
Alternate Names	ABC transporter ABC15 ABCPMGC102821 ATP-binding cassette sub-family G member 2 ATP-binding cassette transporter G2 ATP-binding cassette, sub-family G (WHITE), member 2 BCRP1 BCRPMRX BMDP Breast cancer resistance protein CD338 antigen CD338 CDw338 EST157481 mitoxantrone resistance protein Mitoxantrone resistance-associated protein MXRMXR1 placenta specific MDR protein Placenta-specific ATP-binding cassette transporter

Research Areas for ABCG2/CD338

Find related products by research area and learn more about each of the different research areas below.

ABC Transporters
Cancer
Cellular Markers
Hematopoietic Stem Cell Markers
Neuronal Cell Markers
Neuronal Stem Cell Markers
Stem Cell Markers