ABCE1 Antibody

Product Discontinued

ABCE1 Antibody Summary

• Immunogen: Peptide with sequence C-KLNSIKDVEQKK corresponding to C-Terminus according to NP_001035809.1.
• Specificity: Variants (NP_002931.2; NP_001035809.1) encode the same protein.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: ABCE1
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Peptide ELISA Detection limit 1:8000
  • Western Blot 0.3 - 1 ug/ml
• Application Notes: WB: Approx. 70 kDa band observed in lysates of A431 (calculated MW of 67.6 kDa band according to NP_002931.1).
• Theoretical MW: 67 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
• Control:

  ABCE1 Overexpression Lysate

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Mouse, Rat, Canine, Bovine.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris (pH 7.3), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for ABCE1 Antibody

• 2'-5'-oligoadenylate-binding protein
• ATP-binding cassette, sub-family E (OABP), member 1
• HuHP68
• OABP
• Ribonuclease 4 inhibitor
• ribonuclease L (2'-5'-oligoisoadenylate synthetase-dependent) inhibitor
• RLIABC38
• RNase L inhibitor
• RNASEL1
• RNASELIRNS4IATP-binding cassette sub-family E member 1

Background

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for ABCE1 Antibody (NB100-94888)(1)

Publication using NB100-94888

• Shichijo S, Ishihara Y, Azuma K et al. ABCE1, a member of ATP-binding cassette transporter gene, encodes peptides capable of inducing HLA-A2-restricted and tumor-reactive cytotoxic T lymphocytes in colon cancer patients. Oncol Rep 2005-05-01 [PMID: 15809757]

Bioinformatics

• Gene Symbol: ABCE1
• Entrez:
  • 6059(Human)
  • 24015(Mouse)
  • 361390(Rat)
• Uniprot:
  • P61221(Human)