ABCC5 Antibody

Immunohistochemistry-Paraffin: ABCC5 Antibody [NB100-94881] - Negative Control showing staining of paraffin embedded Human Kidney, with no primary antibody.

Immunohistochemistry-Paraffin: ABCC5 Antibody [NB100-94881] - staining of paraffin embedded Human Kidney. Antibody at 5 ug/mL. Heat induced antigen retrieval with citrate buffer pH 6, HRP-staining.

• Reactivity: Hu, Mu, Rt, Po, Bv, Ca
• Applications: ELISA, IHC
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Unconjugated
• Concentration: 0.5 mg/ml

ABCC5 Antibody Summary

• Description: Novus Biologicals Goat ABCC5 Antibody (NB100-94881) is a polyclonal antibody validated for use in IHC and ELISA. Anti-ABCC5 Antibody: Cited in 1 publication. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: Peptide with sequence KDIDIGKEYIIP-C corresponding to N-Terminus according to NP_001018881.1.
• Specificity: This antibody is expected to recognize both reported isoforms (NP_005679.2; NP_001018881.1).
• Predicted Species: Mouse (100%), Rat (100%), Porcine (100%), Bovine (100%), Canine (100%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: ABCC5
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 5 ug/mL
  • Immunohistochemistry-Paraffin 5 ug/mL
  • Peptide ELISA Detection limit 1:28000
• Theoretical MW: 161 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for ABCC5 Antibody

• ABCC5
• ATP-binding cassette sub-family C member 5
• ATP-binding cassette, sub-family C (CFTR/MRP), member 5
• canalicular multispecific organic anion transporter C
• EC 7.6.2.-
• EC 7.6.2.2
• EST277145
• MOAT-C
• MOAT-CABC33
• MRP5
• MRP5MOATC
• multidrug resistance-associated protein 5
• Multi-specific organic anion transporter C
• pABC11
• SMRP
• SMRPDKFZp686C1782

Background

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has been detected; however, the complete sequence and translation initiation site is unclear. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for ABCC5 Antibody (NB100-94881)(1)

Publication using NB100-94881

• Meyer Zu Schwabedissen HE, Grube M, Heydrich B et al. Expression, localization, and function of MRP5 (ABCC5), a transporter for cyclic nucleotides, in human placenta and cultured human trophoblasts: effects of gestational age and cellular differentiation Am J Pathol 2005-01-01 [PMID: 15631998]

Bioinformatics

• Gene Symbol: ABCC5
• Entrez:
  • 10057(Human)
  • 27416(Mouse)
  • 116721(Rat)
• Uniprot:
  • Q86W30(Human)