ABCC5 Antibody

Images

 
Western Blot: ABCC5 Antibody [NB100-94881] - Staining of Human Frontal Cortex lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Immunohistochemistry-Paraffin: ABCC5 Antibody [NB100-94881] - Staining of paraffin embedded Human Liver. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
Immunohistochemistry-Paraffin: ABCC5 Antibody [NB100-94881] - Staining of paraffin embedded Human Kidney. Steamed antigen retrieval with citrate buffer pH 6, HRP-staining. Similar results with antigen retrieval at pH9.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IHC, IHC-P, PEP-ELISA
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
0.5 mg/ml

Order Details

ABCC5 Antibody Summary

Immunogen
Peptide with sequence KDIDIGKEYIIP-C corresponding to N-Terminus according to NP_001018881.1.
Specificity
This antibody is expected to recognize both reported isoforms (NP_005679.2; NP_001018881.1).
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
ABCC5
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 0.5 - 1.5 ug/ml
  • Immunohistochemistry 4 - 6 ug/ml
  • Immunohistochemistry-Paraffin 4 - 6 ug/ml
  • Peptide ELISA Detection limit 1:32000
Application Notes
WB: Approx. 150 kDa band observed in human brain (frontal cortex) and mouse brain lysates (calculated MW of 161 kDa band according to NP_005679.2). IHC-P: Human kidney shows membranous staining in DCT. IHC: In paraffin embedded Human Kidney shows membranous staining in DCT. Paraffin embedded Human Liver.
Theoretical MW
161 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Publications
Read Publication using NB100-94881.

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Mouse, Rat. Canine, Porcine, Bovine.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
0.5 mg/ml Tris (pH 7.3) and 0.5% BSA
Preservative
0.02% Sodium Azide
Concentration
0.5 mg/ml
Purity
Immunogen affinity purified

Alternate Names for ABCC5 Antibody

  • ATP-binding cassette sub-family C member 5
  • ATP-binding cassette, sub-family C (CFTR/MRP), member 5
  • canalicular multispecific organic anion transporter C
  • EST277145
  • MOAT-CABC33
  • MRP5MOATC
  • multidrug resistance-associated protein 5
  • Multi-specific organic anion transporter C
  • pABC11
  • SMRPDKFZp686C1782

Background

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has been detected; however, the complete sequence and translation initiation site is unclear. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for ABCC5 Antibody (NB100-94881)(1)

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Bioinformatics

Gene Symbol ABCC5
Entrez
Uniprot