5-HT6 Antibody (2157A) [Alexa Fluor® 647]

• Reactivity: Hu
• Applications: IHC
• Clone: 2157A
• Clonality: Monoclonal
• Host: Rabbit
• Conjugate: Alexa Fluor 647

5-HT6 Antibody (2157A) [Alexa Fluor® 647] Summary

• Additional Information: Recombinant Monoclonal Antibody.
• Immunogen: Human 5-HT6 peptide
  Accession # P50406
• Specificity: Detects human 5-HT6 in direct ELISAs.
• Isotype: IgG
• Clonality: Monoclonal
• Host: Rabbit
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for 5-HT6 Antibody (2157A) [Alexa Fluor® 647]

• 5-HT6
• 5-hydroxytryptamine (serotonin) receptor 6,5-HT65-HT6R
• HTR6
• Serotonin receptor 6,5-HT-6,5-hydroxytryptamine receptor 6

Background

5-HT6 is a seven transmembrane G-protein coupled 1 receptor for serotonin, with 93% homology between human and rat, and with highest expression in neurons of the striatum, cortex and hippocampus. Expression in cultured primary astrocytes from rats and glia has also been demonstrated for most brain regions. Expression in lymph node, spleen and testis has also been observed. High affinity for psychotropic drugs including tricyclic antidepressants and antipsychotics and high expression in the limbic regions suggest a role for 5-HT6 in emotional behaviors and mental illness. Lower expression of 5-HT6 in cortical layers I-V have been observe in Alzheimer's Disease brains.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.