5-HT2B Antibody


Immunohistochemistry-Paraffin: 5-HT2B Antibody [NLS1187] - Analysis of anti-5HT2B Receptor antibody with human brain, neurons and glia.
Immunohistochemistry-Paraffin: 5-HT2B Antibody [NLS1187] - Kidney, Renal tubules

Product Details

Reactivity HuSpecies Glossary
Applications IHC-P
1.0 mg/ml

Order Details

5-HT2B Antibody Summary

A 20 amino acid synthetic peptide within the N-terminal extracellular domain of human 5HT2B Receptor.
Cell Membrane
Human 5HT2B Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Predicted Species
Primate (95%), Monkey (100%), Bat (95%), Equine (90%)
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Packaging, Storage & Formulations

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
0.1% Sodium Azide
1.0 mg/ml
Immunogen affinity purified

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Chimpanzee (100%), Gorilla (100%), Orangutan (100%), Canine (85%), Panda (85%), Bovine (80%), Rabbit (80%).

Alternate Names for 5-HT2B Antibody

  • 5-HT(2B)
  • 5HT2B
  • 5-HT-2B
  • 5-HT2B5-HT 2B receptor
  • 5-hydroxytryptamine (serotonin) receptor 2B
  • 5-hydroxytryptamine 2B receptor
  • 5-hydroxytryptamine receptor 2B
  • HTR2B
  • Serotonin receptor 2B


5-HT2B, a Serotonin Receptor, activates phospholipase C upon binding serotonin, which results in a rise in intracellular calcium. It is known that 5-HT2B regulates cardiovascular function during development and in adulthood; mice lacking functional 5-HT2B receptors died of heart defects during gestation or neonatally, and adult mutant mice displayed cardiopathy, including myocyte disarray and ventricular dilation. Abnormal vascular proliferation causes an increase in pulmonary blood pressure, which is associated with an increase in 5-HT2B receptor, resulting in the development of pulmonary hypertension. It has also been reported that the 5-HT2B is involved in cell-cycle regulation via interaction with tyrosine kinase pathways. 5-HT2B receptors may have a role in the initiation of migraine headaches, and selective antagonists may prove therapeutic in migraine treatment. 5-HT2B receptor is expressed in many tissues including human liver, kidney, lung, heart, pancreas, spleen, brain, spinal cord, gastrointestinal tract, placenta, and coronary and pulmonary arteries. It has also been reported in embryonic mouse heart and spinal cord. ESTs have been isolated from heart/melanocyte/uterus, kidney, prostate, skin, and thyroid libraries.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Customers Who Viewed This Item Also Viewed...

Species: Hu
Applications: ICC/IF, IHC, IHC-P
Species: Hu
Applications: Flow, IHC
Species: Hu, Mu, Rt
Applications: WB
Species: Hu, Mu, Rt
Applications: WB
Species: Hu, Bt, Bv, Ca, Eq, GP, Ha, Rb
Applications: IHC-P
Species: Hu, Mu
Applications: WB, Simple Western
Species: Hu, Mu, Rt, Ca
Applications: WB, ICC/IF
Species: Hu
Applications: WB, IHC, IHC-P
Species: Hu, Rt
Applications: ELISA, IP, S-ELISA
Species: Hu, Rt, Ca, Mk
Applications: WB, IHC, IHC-P, IP
Species: Mu, Rt
Applications: WB, IHC
Species: Hu, Mu, Rt
Applications: WB, Simple Western
Species: Hu, Mu
Applications: WB, Flow, IHC, ICC
Species: Hu, Mu, Rt, Bv, Ha, Pm
Applications: WB, Simple Western, B/N, DB, EM, ICC/IF, IHC, IP, PA
Species: Hu, Mu, Rt
Applications: WB, IHC, IHC-P
Species: Hu, Equine, Primate, Bat, Monkey
Applications: IHC-P

Publications for 5-HT2B Antibody (NLS1187) (0)

There are no publications for 5-HT2B Antibody (NLS1187).
By submitting your publication information earn gift cards and discounts for future purchases.

Reviews for 5-HT2B Antibody (NLS1187) (0)

There are no reviews for 5-HT2B Antibody (NLS1187). By submitting a review earn points towards our Rewards Program.
  • 250 points for product review
  • 500 additional points for an image with your product review
  • Double points (500) if you are the first to review this product
  • Double points (1000) if you are the first to review this product with an image

Product General Protocols

View specific protocols for 5-HT2B Antibody (NLS1187): Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

FAQs for 5-HT2B Antibody (NLS1187) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Positive Control Lysate(s)

Secondary Antibodies


Isotype Controls

Additional 5-HT2B Antibody Products

Related Products by Gene

Bioinformatics Tool for 5-HT2B Antibody (NLS1187)

Discover related pathways, diseases and genes to 5-HT2B Antibody (NLS1187). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Visit Tool

Diseases for 5-HT2B Antibody (NLS1187)

Discover more about diseases related to 5-HT2B Antibody (NLS1187).

Pathways for 5-HT2B Antibody (NLS1187)

View related products by pathway.

PTMs for 5-HT2B Antibody (NLS1187)

Learn more about PTMs related to 5-HT2B Antibody (NLS1187).

Research Areas for 5-HT2B Antibody (NLS1187)

Find related products by research area.

Blogs on 5-HT2B

There are no specific blogs for 5-HT2B, but you can read our latest blog posts.

Contact Information

Product PDFs


Gene Symbol HTR2B

Customer Resources

Novus Review - Submit your review and earn rewards points which can be used for merchandise & discounts.
Risk Free Testing - Test on a species/application not listed above to receive a full credit towards a future purchase.

Novus' Quality Guarantee - Novus guarantees that every product we sell will work in the application and species listed on our website and datasheets.

Submit your question on NLS1187 below.
During business hours, we will respond to your email within 24 hours. For any questions submitted on the weekend, a response will be received on Monday.
For immediate assistance during business hours M- F (excluding major holidays), please contact us.
Ask a Scientist - We have a lab full of white coats just waiting for your scientific questions and concerns.

Customers Who Bought This Also Bought