Recombinant Mouse 4-1BB Ligand/TNFSF9 Protein

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Functional: Recombinant Mouse 4-1BB Ligand/TNFSF9 Protein [NBP2-26580] - Demonstration of the potency of mCD137L fusion protein in vitro in comparison to an agonist antibody 2A. Balb/c mouse splenocytes were incubated ...read more
SDS-Page: Recombinant Mouse 4-1BB Ligand/TNFSF9 Protein [NBP2-26580] - Electrophoretic analysis of the purified Fc-mCD137L using Coomassie Blue stained 4-20% reducing SDS-PAGE.

Product Details

Summary
Reactivity MuSpecies Glossary
Applications Func, PAGE
Concentration
2.0 mg/ml

Order Details

Recombinant Mouse 4-1BB Ligand/TNFSF9 Protein Summary

Description
A recombinant protein corresponding to TNFSF9.

Amino Acid Sequence: EPRGPTIKPCPPCKCPAPNLLGGPSVFIFPPKIKDVLMISLSPIVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTLRVVSALPIQHQDWMSGKEFKCKVNNKDLPAPIERTISKPKGSVRAPQVYVLPPPEEEMTKKQVTLTCMVTDFMPEDIYVEWTNNGKTELNYKNTEPVLDSDGSYFMYSKLRVEKKNWVERNSYSCSVVHEGLHNHHTTKSFSRTPGKSGRTEPRPALTITTSPNLGTRENNADQVTPVSHIGCPNTTQQGSPVFAKLLAKNQASLCNTTLNWHSQDGAGSSYLSQGLRYEEDKKELVVDSPGLYYVFLELKLSPTFTNTGHKVQGWVSLVLQAKPQVDDFDNLALTVELFPCSMENKLVDRSWSQLLLLKAGHRLSVGLRAYLHGAQDAYRDWELSYPNTTSFGLFLVKPDNPWE
Mouse Ig-Fc amino acid sequences are in Italics
Linker sequence (SGR) in bold
Mouse CD137L sequences are underlined

Details of Functionality
In vitro proliferation assay, in vivo assays.
Protein/Peptide Type
Recombinant Protein
Gene
TNFSF9
Purity
Protein A purified
Endotoxin Note
Endotoxin level < 0.1 EU/ug of the protein (< 0.01 ng/ug of the protein) as determined by the LAL test.

Applications/Dilutions

Publications
Read Publication using NBP2-26580.

Packaging, Storage & Formulations

Storage
Store at -80C. Avoid freeze-thaw cycles.
Buffer
Phosphate-buffered solution, pH 7.2, containing no preservative. 0.2 um filter sterilized.
Concentration
2.0 mg/ml
Purity
Protein A purified

Alternate Names for Recombinant Mouse 4-1BB Ligand/TNFSF9 Protein

  • 41BB Ligand
  • 4-1BB Ligand
  • 4-1BBL
  • 4-1BB-L
  • CD137L
  • homolog of mouse 4-1BB-L
  • receptor 4-1BB ligand
  • TNFSF9
  • tumor necrosis factor (ligand) superfamily, member 9
  • tumor necrosis factor ligand superfamily member 9

Background

CD137L is a member of the TNF superfamily and provides costimulatory signals to T cells. It is expressed on dendritic cells, activated macrophages, and B cells. CD137L binds to its receptor CD137 on activated T cells, this interaction is important for adaptive T-cell response. The engagement of CD137 by CD137L provides costimulation to both CD4+ and CD8+ cells. Agonist anti-CD137 monoclonal antibodies also have been used to stimulate CD137 to regulate T-cell number and functions. The Fc-CD137L fusion protein was generated by cloning the extracellular domain of mouse CD137L with the Fc region of mouse immunoglobulin (hinge region, CH2, CH3 domains). The Fc-CD137L fusion protein has comparable biological activities as 2A, a CD137 agonist antibody.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

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Bioinformatics

Gene Symbol TNFSF9