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Desmin Antibody (Y66)

 (9 Publications)
 (2 Reviews)
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Summary
Product Discontinued
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    • Catalog Number
      NB110-56931
    • Availability
      Product Discontinued

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Desmin Antibody (Y66) Summary

Immunogen
A synthetic peptide corresponding to C-terminus of human Desmin was used as immunogen.
Isotype
IgG
Clonality
Monoclonal
Host
Rabbit
Gene
DES
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovator's Reward

Applications/Dilutions

Dilutions
  • Flow Cytometry 1:10-100
  • Immunocytochemistry/ Immunofluorescence 1:10-1:500
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
  • Western Blot 1:1000-10000
Application Notes
This product is useful for: Western Blot, Immunohistochemistry-Paraffin. Immunocytochemistry/Immunofluorescence was reported in scientific literature. In Western blot this antibody detects a band at approximately 53kDa.
Theoretical MW
53 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Control
Desmin Overexpression Lysate
Reviewed Applications
Read 2 Reviews rated 5
using
NB110-56931 in the following applications:
Publications
Read Publications using
NB110-56931 in the following applications:

Reactivity Notes

Guines Pig reactivity reported in scientific literature (PMID: 22027755). Sheep from review data.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
59% PBS (pH 7.2), 0.05% BSA and 40% Glycerol
Preservative
0.01% Sodium Azide
Purity
Protein A or G purified

Notes

Produced using Abcam's RabMab® technology. RabMab® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

Alternate Names for Desmin Antibody (Y66)

  • CMD1I
  • CMD1IFLJ41013
  • CSM1
  • CSM2
  • DES
  • Desmin
  • FLJ12025
  • FLJ39719
  • FLJ41793
  • intermediate filament protein

Background

Desmin are class-III intermediate filaments found in muscle cells, and are expressed during the formation of muscle cells or fibers. Cytoskeletal intermediate filaments (IFs) are constructed from two-chain alpha-helical coiled-coil molecules arranged on an imperfect helical lattice (1,2). In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures. Desmin mutations have been linked to familial cardiac and skeletal myopathy (3,4).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Desmin Antibody (NB110-56931)(9)

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 4 applications: FLOW, ICC/IF, IF/IHC, WB.


Filter By Application
FLOW
(1)
ICC/IF
(3)
IF/IHC
(1)
WB
(1)
All Applications
Filter By Species
Human
(1)
Mouse
(2)
All Species
Showing Publications 1 - 9 of 9.
Publications using NB110-56931 Applications Species
Weiskirchen S, Tag CG, Sauer-Lehnen S et al. Isolation and Culture of Primary Murine Hepatic Stellate Cells Methods Mol. Biol. 2017-08-24 [PMID: 28836201] (FLOW, Mouse) FLOW Mouse
Tannour-Louet M, Han S, Louet JF et al. Increased gene copy number of the vesicle SNARE VAMP7 disrupts human male urogenital development through altered estrogen action. Nat Med 2014-07-01 [PMID: 24880616]
Koning M, Werker PM, van Luyn MJ et al. A global downregulation of microRNAs occurs in human quiescent satellite cells during myogenesis Differentiation 2012-11-01 [PMID: 23023067] (ICC/IF, Human) ICC/IF Human
Li L, Haider HKh, Wang L, Lu G, Ashraf M. Adenoviral short hairpin RNA therapy targeting phosphodiesterase 5a relieves cardiac remodeling and dysfunction following myocardial infarction. Am J Physiol Heart Circ Physiol;302(10):H2112-21. 2012-05-01 [PMID: 22447941] (IF/IHC, ICC/IF, Mouse) IF/IHC, ICC/IF Mouse
Ahmed RP, Ashraf M, Buccini S et al. Cardiac tumorgenic potential of induced pluripotent stem cells in an immunocompetent host with myocardial infarction. Regen Med. 2011-03-01 [PMID: 21391851]
Dai M, Yang Y, Omelchenko I et al. Bone marrow cell recruitment mediated by inducible nitric oxide synthase/stromal cell-derived factor-1alpha signaling repairs the acoustically damaged cochlear blood-labyrinth barrier. Am J Pathol 2010-12-01 [PMID: 21057001]
Kaza E, Ablasser K, Poutias D et al. Up-regulation of soluble vascular endothelial growth factor receptor-1 prevents angiogenesis in hypertrophied myocardium. Cardiovasc Res 2011-02-01 [PMID: 20935166]
Galeano B, Klootwijk R, Manoli I et al. Mutation in the key enzyme of sialic acid biosynthesis causes severe glomerular proteinuria and is rescued by N-acetylmannosamine. J Clin Invest 2007-06-01 [PMID: 17549255] (WB) WB
Yoon S, Molloy MJ, Wu MP et al. C6ORF32 is upregulated during muscle cell differentiation and induces the formation of cellular filopodia. Dev Biol 2007-01-01 [PMID: 17150207] (ICC/IF) ICC/IF

Reviews for Desmin Antibody (NB110-56931) (2) 52

Average Rating: 5
(Based on 2 reviews)
We have 2 reviews tested in 2 species: Rat, Other.

Reviews using NB110-56931:
Filter by Applications
IHC-P
(2)
All Applications
Filter by Species
Rat
(1)
Other
(1)
All Species
Images Ratings Applications Species Date Details
Immunohistochemistry-Paraffin Desmin NB110-56931
Enlarge 		5
reviewed by:
Naiche Adler
 IHC-P Rat 03/26/2015
View

Summary

ApplicationImmunohistochemistry-Paraffin
Sample Testedrat major blood vessels
SpeciesRat
Immunohistochemistry-Paraffin Desmin NB110-56931
Enlarge 		5
reviewed by:
Bryan Tinsley
 IHC-P Other 05/20/2014
View

Summary

ApplicationImmunohistochemistry-Paraffin
Sample TestedOvine Heart
SpeciesOther

Product General Protocols

View specific protocols for Desmin Antibody (NB110-56931): Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for Desmin Antibody (NB110-56931). (Showing 1 - 1 of 1 FAQs).

  1. Has this antibody already been tested for flow cytometry? Are there any references for the use in flow available?
    • NB110-56931 has been tested and validated for use in Flow cytometry, as stated by our datasheet. Unfortunately, at this time there are no references of this antibody used in flow cytometry available.

Control Lysate(s)

Desmin Overexpression Lysate

Secondary Antibodies

 

Isotype Controls

Additional Desmin Products

Research Areas for Desmin Antibody (NB110-56931)

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Blogs on Desmin.

Check out the latest blog posts on Desmin.
Alpha-smooth muscle actin and the modulation of endothelial and epithelial cell biology
Actin is essential for a wide range of cell functions, ranging from cell division and chromatin remodeling to vesicle trafficking and maintenance of cellular structure. In fact, mislocalization of actin to cell junctions during development leads t...  Read full blog post.
Vimentin in Wound Healing
Vimentin is a fundamental 10 nm type III intermediate filament (IF) protein found in many mesenchymal and epithelia tissues, tissue culture cells, and developing neuronal and astrocytic precursor cells of the central nervous system. It frequently co-p...  Read full blog post.

Contact Information

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Recent Reviews

5
5
2
4
0
3
0
2
0
1
0
Immunohistochemistry-Paraffin Desmin NB110-56931
Enlarge
 Naiche Adler
03/26/2015
Application: IHC-P
Species: Rat
read this review
Immunohistochemistry-Paraffin Desmin NB110-56931
Enlarge
 Bryan Tinsley
05/20/2014
Application: IHC-P
Species: Other
read this review

Bioinformatics

Gene Symbol DES
Entrez
Uniprot