CD3 epsilon Antibody (145-2C11)

CD3 is a multi-subunit complex consisting of 4 different invariable membrane proteins, CD3E, CD3D, CD3G and CD3-omega. These CD3 proteins are expressed on the surface of T-cells and Thymocytes during thymocyte development. They are non-covalently associated with the TCR heterodimer and form the functional TCR-CD3 antigen receptor complex of the T-lymphocyte. CD3 expression is significant during Intrathymic T-lymphocyte maturation, TCR signaling and Thymocyte differentiation. Stimulation of TCR-CD3 complex results in activation of various protein tyrosine kinases including ZAP-70 affecting multiple cellular responses including T-cell proliferation, clonal expansion, induction of tolerance and apoptosis. Mutations in the sub-unit chains of CD3 have been associated with various immunodeficiency syndromes including SCID.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 2 applications: FLOW, ICC/IF.

Showing Publications 1 - 3 of 3.

Publications using NBP2-30151	Applications	Species
Lennon, S;Oweida, A;Milner, D;Phan, AV;Bhatia, S;Van Court, B;Darragh, L;Mueller, AC;Raben, D;Martinez-Torrecuadrada, JL;Pitts, TM;Somerset, H;Jordan, KR;Hansen, KC;Williams, J;Messersmith, WA;Schulick, RD;Owens, P;Goodman, KA;Karam, SD; Pancreatic Tumor Microenvironment Modulation by EphB4-ephrinB2 Inhibition and Radiation Combination Clin. Cancer Res. 2019-04-03 [PMID: 30944125] (FLOW, Human)	FLOW	Human
Oweida A, Hararah M, Phan AV et al. Resistance to radiotherapy and PD-L1 blockade is mediated by TIM-3 upregulation and regulatory T-cell infiltration Clin. Cancer Res. 2018-07-24 [PMID: 30042205] (FLOW, Mouse)	FLOW	Mouse
Mayo L, Cunha AP, Madi A et al. IL-10-dependent Tr1 cells attenuate astrocyte activation and ameliorate chronic central nervous system inflammation. Brain. 2016-07-01 [PMID: 27246324] (ICC/IF, Mouse) Details: This citation used the DyLight 755 version of this antibody.	ICC/IF	Mouse

Array NBP2-30151

• CD3 epsilon Antibodies
• CD3 epsilon ELISA Kit
• CD3 epsilon Lysate
• CD3 epsilon Proteins
• CD3 epsilon Proteins and Enzyme